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Three PRO14 matches take place on Saturday with Edinburgh versus Cardiff the big game before Sunday sees Scarlets host the Cheetahs.
There are four Premiership games scheduled for Saturday, including Wasps against Sale, with one match concluding the round on Sunday.
Two teams who are in a state of uncertainty will open Round Three of the Six Nations as France and Scotland go head-to-head in Paris.
The Highlanders continued with their fine start to the season when they edged out the Reds 36-31 in a thrilling encounter in Dunedin on Friday.
The two remaining unbeaten teams in this year’s Six Nations will face off at the Principality Stadium on Saturday when Wales host England.
All Blacks and Chiefs playmaker Damian McKenzie is looking forward to getting onto the field against the Brumbies in Canberra this Saturday.
Check out the team line-ups ahead of Round Two of Super Rugby.
There’s three PRO14 games scheduled on Friday as Glasgow, Ospreys and Leinster host Connacht, Munster and Southern Kings respectively.
Gloucester will be looking to follow up last week’s victory over Exeter Chiefs when they take on new Premiership leaders Saracens on Friday.
Wales head coach Warren Gatland has opted to start Gareth Anscombe at fly-half ahead of Dan Biggar for their Six Nations clash with England.
England head coach Eddie Jones has made two changes to his team to face Wales on Saturday with Jack Nowell and Ben Moon handed starts.
Scotland have made four changes to their starting XV to face France in this Saturday’s Six Nations clash in Paris, with Pete Horne named at 10.
The Blues have welcomed three All Blacks into their starting XV to take on the Sharks in their Super Rugby encounter in Durban on Saturday.
Chiefs co-captain Brodie Retallick will play his 100th Super Rugby game for the franchise on Saturday when they face the Brumbies in Canberra.
Hurricanes captain Dane Coles will return to their starting line-up for the first time since 2017 when they take on the Crusaders on Saturday.
Crusaders head coach Scott Robertson has made just one alteration to his starting line-up to face the Hurricanes in Christchurch on Saturday.
Cheetahs back Nico Lee has been suspended for 13 weeks following an incident that took place in the second half of their game at Connacht.