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Four games take place on Saturday with Cheetahs, Dragons, Kings and Cardiff hosting Zebre, Munster, Edinburgh and Connacht respectively.
Four games take place in the European Challenge Cup on Friday with Harlequins and Benetton looking to secure qualification from Pool 5.
Wales defence coach Shaun Edwards has admitted that he “fancied” taking the Dragons head coach’s job before deciding against it.
Dragons chairman David Buttress has confirmed Ceri Jones has been appointed as the region’s coach until the end of the current season.
The Dragons have announced that second-row Rynard Landman has signed a three-month loan contract with Pro D2 outfit Angouleme.
Four fixtures are scheduled in the Challenge Cup on Friday as Round Five begins, with Pool 4 pace-setters La Rochelle and Zebre facing off.
Champions Leinster returned to the victory trail in the PRO14 when they secured a 40-7 victory over Ulster at the RDS Arena on Saturday.