The Test action kicks off in Tokyo where Japan host the world champions, New Zealand, before Wales and Scotland do battle for the Doddie Weir Cup in Cardiff and Ireland and Italy go head-to-head in Chicago.
See who we’re backing below.
England v South Africa
Prediction: South Africa may be without Faf de Klerk but England have so many injuries that the visitors should take it. Springboks by six.
Japan v New Zealand
Prediction: Although this is an inexperienced All Blacks side, they will still have too much firepower for their hosts. New Zealand to win by 20 points.
Wales v Scotland
Prediction: There shouldn’t be too much to choose between the sides. Wales by 10!
Ireland v Italy
Prediction: It’s tough to see Italy coming close at Soldier Field. Ireland by 25.
Edinburgh v Scarlets: Scarlets by 8
Ospreys v Glasgow Warriors: Glasgow Warriors by 6
Connacht v Dragons: Connacht by 9
Benetton Rugby v Ulster: Ulster by 5
Cardiff Blues v Zebre: Cardiff Blues by 7
Cheetahs v Munster: Munster by 6
Southern Kings v Leinster: Leinster by 10
Grenoble v Clermont: Clermont by 11
Castres v Pau: Castres by 8
Toulon v Perpignan: Toulon by 5
La Rochelle v Agen: La Rochelle by 9
Toulouse v Bordeaux Bègles: Toulouse by 7
Lyon v Stade Français: Stade Français by 4
Montpellier v Racing 92: Racing 92 by 3