Argentina head coach Daniel Hourcade has made just one change to his starting line-up to face Wales, with Martin Landajo coming in at nine.
Landajo replaces the benched Gonzalo Bertranou in the only tweak to the matchday squad as the Pumas look to bounce back from San Juan.
This fixture in Santa Fe is the last in the series with Wales so Argentina know they must win at Estadio Brigadier Lopez to share the spoils.
Last weekend they lost 23-10 so will be eyeing for a much-improved showing, with their international form in recent years a real concern.
Argentina: 15 Emiliano Boffelli, 14 Bautista Delguy, 13 Matias Orlando, 12 Jeronimo de le Fuente, 11 Ramiro Moyano, 10 Nicolas Sanchez, 9 Martin Landajo, 8 Javier Ortega Desio, 7 Marcos Kremer, 6 Pablo Matera, 5 Tomas Lavanini, 4 Guido Petti, 3 Nahuel Tetaz Chaparro, 2 Agustin Creevy (c), 1 Santiago Garcia Botta
Replacements: 16 Julian Montoya, 17 Javier Diaz, 18 Santiago Medrano, 19 Matias Alemanno, 20 Tomas Lezana, 21 Gonzalo Bertranou, 22 Santiago Gonzalez Iglesias, 23 Sebastian Cancelliere
Date: Saturday, June 16
Venue: Estadio Brigadier Estanislao López
Kick-off: 16:40 local (20:40 BST, 19:40 GMT)
Referee: Jaco Peyper (South Africa)
Assistant referees: Mathieu Raynal (France), Andrew Brace (Ireland)
Television match official: Marius Jonker (South Africa)