Centre Fraser Lyle will make his home debut and scrum-half Ali Price will start his first game at Scotstoun when Glasgow Warriors take on Ospreys.
Edinburgh second-row Fraser McKenzie could make his Warriors debut from the bench, after joining the club on a short-term deal this week, while full-back Glenn Bryce could make his second appearance for the Warriors and first at Scotstoun.
26-year-old Lyle started his first game for the club last weekend and scored in the 54-10 win over Zebre, while it will be 21-year-old Price's second start for the club and fourth appearance.
The Warriors starting XV includes nine internationals, six of which have played for Scotland. There are two positional switches and four personnel changes to the team which beat Zebre in Parma on Sunday to move to the top of the Pro12
After scoring two tries in the last game, Peter Murchie is retained at full-back, while Niko Matawalu moves from scrum-half to the right wing to replace the injured Lee Jones. Canadian winger DTH van der Merwe continues on the opposite wing, while Richie Vernon and Lyle continue their centre partnership.
After scoring a brace against Zebre and being named man of the match, Peter Horne continues at fly-half, with Price wearing the number nine jersey. In the pack Ryan Grant returns to the side and starts at loose-head in place of Alex Allan, who is on the bench. Pat MacArthur continues at hooker and Rossouw de Klerk comes in for Mike Cusack at tight-head. Leone Nakarawa moves from number eight into the second-row and will partner captain Al Kellock in the engine room.
James Eddie and Tyrone Holmes once again start at blind-side and open-side respectively, while Josh Strauss comes in at number eight after making a second-half substitute appearance last Sunday following his return from injury.
After scoring for Scotland under-20s last weekend in their win over Wales, prop Zander Fagerson is named on the bench for the first time since November. One of last weekend's try scorers Will Bordill and on-loan Canadian back Connor Braid are also named amongst the replacements.
Meanwhile, Justin Tipuric returns from Wales duty to start at openside flanker for the Ospreys visit north.
Tyler Ardron captains the Welsh region at Scotstoun while Wales prop Aaron Jarvis also starts having faced Scotland last Sunday.
"It's crucial that we put in a much improved performance after the disappointment of last weekend in Edinburgh. We know how tough it's going to be going to a Glasgow team that has been playing really well and is full of confidence, so we need to make a huge step up in terms of what we did last time out," said Ospreys head coach Steve Tandy.
"We've got some of our international boys back in the mix this week, and it's a first game in more than a year for Ryan Bevington, so we are looking a little better in terms of depth, but we have to make that count, particularly at the start of a three game run that will be massive in terms of the end of season run-in and the play-off spots."
Form: Glasgow Warriors' only Guinness PRO12 defeat since Round Eight was away in Edinburgh on 2 January. The Warriors have won their last fifteen PRO12 matches played at Scotstoun since the Dragons beat them there in November 2013. Glasgow’s only loss in their last seven fixtures with Welsh regions was 9-19 at Scarlets in the PRO12 in November. Ospreys only win in their last five matches in all competitions was 13-10 at Bath in the Anglo-Welsh Cup on 7 February. The Welshmen have been defeated in their last four away games in the PRO12 since they won 15-14 at Zebre in Round Five. Ospreys' only win in their last ten visits to Scotland since 2009 was 15-14 over Edinburgh at Murrayfield in February 2012. Glasgow Warriors have won their last six fixtures against Ospreys since the Welshmen were victorious 37-6 at Liberty Stadium in March 2011 whilst the last time that Ospreys won on Glasgow soil came at Firhill in September 2009.
Glasgow Warriors: 15 Peter Murchie, 14 Niko Matawalu, 13 Richie Vernon, 12 Fraser Lyle, 11 DTH van der Merwe, 10 Peter Horne, 9 Ali Price, 8 Josh Strauss, 7 Tyrone Holmes, 6 James Eddie, 5 Al Kellock (c), 4 Leone Nakarawa, 3 Rossouw de Klerk, 2 Pat MacArthur, 1 Ryan Grant
Replacements: 16 Kevin Bryce, 17 Alex Allan, 18 Zander Fagerson, 19 Fraser McKenzie, 20 Will Bordill, 21 Connor Braid, 22 Rory Hughes, 23 Glenn Bryce
Ospreys: 15 Dan Evans, 14 Tom Grabham, 13 Jonathan Spratt, 12 Josh Matavesi, 11 Dafydd Howells, 10 Sam Davies, 9 Martin Roberts, 8 Dan Baker, 7 Justin Tipuric, 6 James King, 5 Tyler Ardron (c), 4 Tevita Cavubati, 3 Aaron Jarvis, 2 Scott Baldwin, 1 Ryan Bevington
Replacements: 16 Scott Otten, 17 Marc Thomas, 18 Dmitri Arhip, 19 Rory Thornton, 20 Joe Bearman, 21 Ieuan Jones, 22 Tom Habberfield, 23 Hanno Dirksen
Date: Saturday, February 21
Venue: Scotstoun Stadium
Kick-off: 17:15 GMT
Referee: George Clancy (Ireland)
Assistant Referees: Andrew McMenemy (Scotland), Neil Paterson (Scotland)
TMO: Jim Yuille (Scotland)