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Rhys Ruddock will captain a new-look Ireland line-up that includes one uncapped player in the 23-man squad to play USA at the Aviva Stadium.
An unchanged South Africa starting side will face Wales in their final November Test of the year at the Principality Stadium on Saturday.
Italy head coach Conor O’Shea has made one change to his starting team that will face New Zealand at the Stadio Olimpico on Saturday.
There are three games scheduled in the PRO14 on Friday as Glasgow host Cardiff Blues, Leinster face Ospreys and Scarlets take on Ulster.
Two matches take place in the Premiership on Friday as Newcastle Falcons host Bath while Worcester Warriors clash with Harlequins.
Wales head coach Warren Gatland has made 14 changes to his starting XV for Saturday’s Test against South Africa at the Principality Stadium.
England head coach Eddie Jones has kept faith with Joe Cokanasiga and Jamie George for their game against Australia at Twickenham.
Argentina have made three alterations to their starting side for their final November Test against Scotland at Murrayfield this Saturday.
France head coach Jacques Brunel has made just two alterations to his starting line-up to face Fiji at the Stade de France in Paris on Saturday.
World Rugby chief executive Brett Gosper wants referees to show more red and yellow cards in a continued effort to stop dangerous tackles.
Defence coach John Mitchell has spoken of his pride at being a part of the England backroom staff again after their recent November Tests.
Rebels and Wallabies front-row Laurie Weeks has announced his retirement from professional rugby with immediate effect.
All Blacks head coach Steve Hansen has made numerous alterations to his starting line-up for their Test against Italy in Rome on Saturday.
France will wear rainbow laces when they take on Fiji at Stade de France on Saturday night in support of Gareth Thomas following his assault.
Russia coach Lyn Jones believes his side have a monumental task on their hands as they prepare to take part in the 2019 Rugby World Cup.
Scotland head coach Gregor Townsend has made nine changes to his starting line-up for Saturday’s Test against Argentina at Murrayfield.
In our last Expert Witness, we welcome back former England and British & Irish Lions fly-half Rob Andrew to preview this week’s Cook Cup clash.
Scotland full-back Stuart Hogg says his ankle is feeling ‘grand’ and has declared himself fit for Saturday’s clash with Argentina at Murrayfield.
Springbok assistant coach Mzwandile Stick praised the squad for the way they’ve adjusted to challenging conditions on their year-end tour.
Finishing their 2018 season with a strong performance is the All Blacks’ aim going into their final game of the year, against Italy on Saturday.