Former Stormers scrum-half Nic Groom could make his Lions debut off the bench when the Lions tackle the Waratahs in Sydney on Friday.
Groom arrives from Northampton Saints, having impressed in a two-year stint in the Premiership. The number nine made 126 appearances for Western Province and the Stormers combined between 2011-2016.
Meanwhile, captain Franco Mostert will move from the lock position to the blindside flank in place of the injured Cyle Brink, with Marvin Orie shifting to number five and Andries Ferreira coming in to join him in the second-row.
The only other change to the starting line-up sees Jacques van Rooyen named at loosehead prop in place of Dylan Smith, who drops out of the matchday 23 altogether.
Lions: 15 Andries Coetzee, 14 Ruan Combrinck, 13 Lionel Mapoe, 12 Harold Vorster, 11 Madosh Tambwe, 10 Elton Jantjies, 9 Dillon Smit, 8 Hacjivah Dayimani, 7 Franco Mostert (c), 6 Kwagga Smith, 5 Marvin Orie, 4 Andries Ferreira, 3 Ruan Dreyer, 2 Malcolm Marx, 1 Jacques van Rooyen.
Replacements: 16 Robbie Coetzee, 17 Dylan Smith, 18 Jacobie Adriaanse, 19 Lourens Erasmus, 20 Marnus Schoeman, 21 Nic Groom, 22 Rohan Janse van Rensburg, 23 Sylvian Mahuza
Date: Friday, April 17
Venue: Allianz Stadium
Kick-off: 19:45 local (09:45 GMT)
Match officials: TBC