In the backline, Yoann Huget shifts from the left wing to full-back, where he replaces Maxime Medard, and Gaël Fickou comes into the run-on side to wear the number 11 jersey.
There is also a new midfield combination with Mathieu Bastareaud and Geoffrey Doumayrou taking over from Wesley Fofana and Romain Ntamack at outside and inside centre respectively.
Amongst the forwards, Yacouba Camara starts on the blindside flank in Wenceslas Lauret’s place while Félix Lambey comes in at lock for Paul Willemse, who drops to the replacements bench.
The final change is in the front-row where Demba Bamba takes over from Uini Atonio at tighthead prop.
On the bench, Dorian Aldegheri and Thomas Ramos could make their Test debuts if they take to the field.
France: 15 Yoann Huget, 14 Damien Penaud, 13 Mathieu Bastareaud, 12 Geoffrey Doumayrou, 11 Gaël Fickou, 10 Camille Lopez, 9 Morgan Parra, 8 Louis Picamoles, 7 Arthur Iturria, 6 Yacouba Camara, 5 Félix Lambey, 4 Sébastien Vahaamahina, 3 Demba Bamba, 2 Guilhem Guirado (c), 1 Jefferson Poirot
Replacements: 16 Pierre Bourgarit, 17 Dany Priso, 18 Dorian Aldegheri, 19 Paul Willemse, 20 Gregory Alldritt, 21 Antoine Dupont, 22 Romain Ntamack, 23 Thomas Ramos
Date: Sunday, February 10
Kick-off: 15:00 GMT
Referee: Nigel Owens (Wales)
Assistant referees: Andrew Brace (Ireland), Brendon Pickerill (New Zealand)
TMO: Glenn Newman (New Zealand)