Springbok fly-half Elton Jantjies will earn his 100th cap in Super Rugby for the Lions when they host the Brumbies in Johannesburg on Saturday.
In the most interesting change, Aphiwe Dyantyi switches from the wing to outside centre, where he will line up alongside Rohan Janse van Rensburg.
Hacjivah Dayimani returns to the starting line-up at the back of the scrum.
Elsewhere, Madosh Tambwe and Sylvian Mahuza will take their positions on the wings while Ross Cronjé, Corné Fourie, Len Massyn and Shaun Reynolds are all new faces on the bench.
Lions: 15 Andries Coetzee, 14 Sylvian Mahuza, 13 Aphiwe Dyantyi, 12 Rohan Janse van Rensburg, 11 Madosh Tambwe, 10 Elton Jantjies, 9 Nic Groom, 8 Hacjivah Dayimani, 7 Franco Mostert (c), 6 Kwagga Smith, 5 Marvin Orie, 4 Lourens Erasmus, 3 Ruan Dreyer, 2 Robbie Coetzee, 1 Dylan Smith
Replacements: 16 Corne Fourie, 17 Jacques van Rooyen, 18 Johannes Jonker, 19 Len Massyn, 20 Marnus Schoeman, 21 Ross Cronje, 22 Shaun Reynolds, 23 Ruan Combrinck
Date: Saturday, May 19
Venue: Ellis Park
Kick-off: 17:15 (15:15 GMT)
Referee: Nick Briant (New Zealand)
Assistant referees: Quinton Immelman (South Africa), Stephen Geldenhuys (South Africa)
Television match official: Marius Jonker (South Africa)