Tighthead prop Wilco Louw will play his 50th match for Western Province in their Currie Cup derby against the Blue Bulls at Loftus Versfeld.
Louw is one of four players who have returned from the Springbok squad to take their place in the starting XV for the final league fixture.
He is joined in the Western Province team by flank Sikhumbuzo Notshe, fly-half Damian Willemse and centre Ruhan Nel.
Having already secured a home semi-final at Newlands next week, Western Province will be looking to seal top spot on the standings by continuing their unbeaten run in the Currie Cup this season.
In the front-row Louw starts alongside hooker Scarra Ntubeni and prop Ali Vermaak, with skipper Chris van Zyl and JD Schickerling the lock pairing.
Notshe is at number eight and will be flanked by Kobus van Dyk and Ernst van Rhyn in the loose trio.
Scrum-half Herschel Jantjies will form an all-new half-back pairing with Willemse, while Dan du Plessis makes his first start of the season in midfield alongside Nel.
The outside back combination of Dillyn Leyds at full-back and wings Sergeal Petersen and SP Marais remains unchanged.
Western Province: 15 Dillyn Leyds, 14 Sergeal Petersen, 13 Ruhan Nel, 12 Dan du Plessis, 11 SP Marais, 10 Damian Willemse, 9 Herschel Jantjies, 8 Sikhumbuzo Notshe, 7 Ernst van Rhyn, 6 Kobus van Dyk, 5 JD Schickerling, 4 Chris van Zyl (c), 3 Wilco Louw, 2 Scarra Ntubeni, 1 Ali Vermaak
Replacements: 16 Chad Solomon, 17 Caylib Oosthuizen, 18 Neethling Fouche, 19 Salmaan Moerat, 20 Jaco Coetzee, 21 Paul de Wet, 22 Josh Stander
Date: Saturday, October 13
Venue: Loftus Versfeld, Pretoria
Kick-off: 17:15 local (16:15 BST, 15:15 GMT)
Referee: Egon Seconds
Assistant referees: Jaco Pretorius, Eduan Nel
Television match official: Lesego Legoete