“Following medical assessments Mako Vunipola has been ruled out of England’s Guinness Six Nations campaign with an ankle ligament injury.
“Vunipola picked up the injury during England’s win against France on Sunday and is expected to be out for 10 weeks,” read the club statement.
“The prop will begin his rehabilitation with Saracens.”
England are currently sitting top of the Six Nations table after recording back-to-back bonus-point victories. They face Wales away next week.