Ireland have made four changes to their backline for their final Autumn Nations Series clash with Argentina at the Aviva Stadium in Dublin on Sunday.
A new half-back pairing of Conor Murray and Joey Carbery starts and Robbie Henshaw makes his season debut at inside centre, partnering Garry Ringrose.
Hugo Keenan gets another chance to impress in the number 15 jersey with wing James Lowe starting his third consecutive game for Ireland. Robert Baloucoune, who made his Ireland debut against the USA in July scoring a scintillating try, gets his second start.
James Ryan is skipper
In the pack, James Ryan assumes the captaincy in the absence of Johnny Sexton and is partnered in second-row by Iain Henderson.
The front-row of Andrew Porter, Ronan Kelleher and Tadgh Furlong is retained as is the back-row of Caelan Doris, Josh van der Flier and Jack Conan.
Dan Sheehan, who won his first cap against Japan earlier this month, and Tom O’Toole, who was capped against USA in July, are named as front-row cover alongside Cian Healy. Tadhg Beirne, Peter O’Mahony, Craig Casey, Harry Byrne and Keith Earls complete the 23.
Ireland: 15 Hugo Keenan, 14 Robert Baloucoune, 13 Garry Ringrose, 12 Robbie Henshaw, 11 James Lowe, 10 Joey Carbery, 9 Conor Murray, 8 Jack Conan, 7 Josh van der Flier, 6 Caelan Doris, 5 James Ryan (c), 4 Iain Henderson, 3 Tadhg Furlong, 2 Ronan Kelleher, 1 Andrew Porter
Replacements: 16 Dan Sheehan, 17 Cian Healy, 18 Tom O’Toole, 19 Tadhg Beirne, 20 Peter O’Mahony, 21 Craig Casey, 22 Harry Byrne, 23 Keith Earls
Date: Sunday, November 21
Venue: Aviva Stadium, Dublin
Kick-off: 14:15 GMT
Referee: Matthew Carley (England)
Assistant Referees: Christophe Ridley (England), Adam Leal (England)
TMO: Tom Foley (England)