Ledesma was disappointed with his side’s scrummaging against the All Blacks, saying after the match they were ‘torn apart’ in that area and has reshuffled his front-row as a result.
Santiago Medrano has replaced Gaston Cortes, with Nahuel Tetaz Chaparro moving to the loosehead.
“We got torn apart so we need to get better there,” Ledesma said after his side’s 46-24 defeat to the All Blacks in Nelson last Saturday.
“It’s been the same for the last couple of years. Unfortunately other teams go hard at us there because they consider we’re really strong.”
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Meanwhile, experienced flanker Pablo Matera returns to the starting XV in place of Tomas Lezana, with veteran Juan Manuel Leguizamon coming in to the matchday 23.
Gonzalo Bertranou comes back in to the side at scrum-half, with Martin Landajo taking up his usual role in the replacements after a rare start last week.
Argentina: 15 Emiliano Boffelli, 14 Bautista Delguy, 13 Matias Moroni, 12 Jeronimo De La Fuente, 11 Ramiro Moyano, 10 Nicolas Sanchez, 9 Gonzalo Bertranou, 8 Javier Ortega Desio, 7 Marcos Kremer, 6 Pablo Matera, 5 Tomas Lavanini, 4 Guido Petti, 3 Santiago Medrano, 2 Agustin Creevy, 1 Nahuel Tetaz Chaparro
Replacements: 16 Julian Montoya, 17 Santiago Garcia Botta, 18 Juan Pablo Zeiss, 19 Matias Alemanno, 20 Juan Manuel Leguizamon, 21 Martin Landajo, 22 Bautista Ezcurra, 23 Juan Cruz Mallia
Date: Saturday, September 15
Venue: Cbus Super Stadium, Gold Coast
Kick-off: 20:00 local (11:00 BST, 10:00 GMT)
Referee: John Lacey (Ireland)
Assistant referees: Glen Jackson (New Zealand), Paul Williams (New Zealand)
Television match official: Glenn Newman (New Zealand)