James Haskell is set to make his first appearance of the season for Wasps in Thursday's clash with Bayonne at Adams Park.
Haskell has been named on the bench for Amlin Challenge Cup fixture, with Wasps welcoming the French outfit to Adams Park for the third time in as many years in this competition. Both sides comfortably won their opening games last weekend with bonus points.
The England back-row is one of a number of changes to the squad which defeated Viadana by a record breaking 90-17 scoreline last weekend, with the result breaking the club's scoring record in Europe.
There's an all new front row with Matt Mullan, Carlo Festuccia and Jake Cooper-Woolley all coming back into the team. In the backs, Andy Goode, Josh Bassett and Charlie Hayter all start in changes there from last weekend.
Joe Launchbury and Haskell are the new additions to the squad this weekend, with both taking their places on the bench.
Sam Jones, Tom Palmer, Ashley Johnson and Elliot Daly miss out with minor knocks while Hugo Southwell, Andrea Masi, Tom Varndell, Phil Swainston, Rory Pitman and James Bailey continue to work through their rehab programmes on their respective injuries.
Meanwhile, Bayonne's new arrival, Pumas centre Santiago Fernandez, has been slotted straight into the starting XV.
London Wasps: 15 Tommy Bell, 14 Christian Wade, 13 Chris Bell, 12 Charlie Hayter, 11 Josh Bassett, 10 Andy Goode, 9 Joe Simpson, 8 Nathan Hughes, 7 Guy Thompson, 6 Ed Jackson, 5 Kearnan Myall, 4 James Cannon, 3 Jake Cooper-Woolley, 2 Carlo Festuccia, 1 Matt Mullan
Replacements: 16 Neil Cochrane, 17 Simon McIntyre, 18 Taoine Vea, 19 Joe Launchbury, 20 James Haskell, 21 Charlie Davies, 22 Joe Carlisle, 23 Ben Jacobs
Bayonne: 15 Scott Spedding, 14 Sam Gerber, 13 Santiago Fernandez, 12 Matthieu Ugalde, 11 Bastien Fuster, 10 Stephen Brett, 9 Mathieu Belie, 8 Opeti Fonua, 7 Jean-Jo Marmouyet, 6 Jean Moribot, 5 Mark Chisolm (c), 4 Lisiate Fa'aose, 3 Gert Muller, 2 David Roumieu, 1 JC Van Rensburg.
Replacements: 16 Gregory Arganese, 17 Aretz Iguiniz, 18 Nemiah Tialata, 19 Dewald Senekal, 20 Guillaume Rouet, 21 Julien Puricelli, 22 Guillaume Bernad, 23 Abdellatif Boutaty,
Date: Thursday, 17 October
Venue: Adams Park
Kick-off: 19.45 local (18.45 BST, 17.45 GMT)
Referee: Peter Fitzgibbon (Ireland)