France captain Thierry Dusautoir will make his return from injury off the Toulouse bench in Friday's Heineken Cup clash with Zebre at Stade Ernest Wallon.
The four-time champions host the Italian side in a true mismatch as the visitors seek their first ever win in the tournament.
Toulouse have never lost to Italian opposition in European competition and have lost just once in their last 14 matches European games on home soil.
Zebre secured their first PRO12 win of their existence away to Cardiff Blues earlier this season but face a much tougher task in the south-west of France.
The Italian side has been strengthened former All Black Brendon Leonard at scrum-half and he starts in his first Heineken Cup game.
Toulouse are currently level with leaders Toulon in the Top 14 table, having won five of their opening nine matches and backs coach Jean-Baptiste Elissalde has urged his side to take no prisoners against the Italians.
"The goal is to get the best in this competition and the best course would be to take five points. But we also have to beware of this team who imposed themselves in Cardiff," the former Toulouse and France scrum-half told the ERC website.
Toulouse warmed up for the clash with a 28-10 victory over Stade Franšais, with wing Yoann Huget grabbing a hat-trick of tries. Huget starts in an all-international back three.
Former Biarritz youngster Jean-Pascal Barraque has been handed the number ten jersey as Luke McAlister sits this one out.
Springbok hooker Chiliboy Ralepelle is also a feature on the Toulouse bench.
Stade Toulousain: 15 Clement Poitrenaud, 14 Yoann Huget, 13 Florian Fritz, 12 Yann David, 11 Maxime Medard, 10 Jean-Pascal Barraque, 9 Sebastien Bezy, 8 Gillian Galan, 7 Yannick Nyanga (c), 6 Gregory Lamboley, 5 Joe Tekori, 4 Romain Millo-Chluski, 3 Yohan Montes, 2 Christopher Tolofua, 1 Gurthro Steenkamp.
Replacements: 16 Chiliboy Ralepelle, 17 Schalk Ferreira, 18 Census Johnston, 19 Louis Picamoles, 20 Patricio Albacete, 21 Jean-Marc Doussain, 22 Hosea Gear, 23 Thierry Dusautoir.
Zebre: 15 Ruggero Trevisan, 14 Giulio Toniolatti, 13 Kameli Ratuvou, 12 Gonzalo Garcia, 11 Dion Berryman, 10 Tommaso Iannone, 9 Brendon Leonard, 8 Samu Vunisa, 7 Dries van Schalkwyk, 6 Mauro Bergamasco, 5 Marco Bortolami (capt), 4 Mike Van Vuren, 3 Carlo Fazzari, 2 Davide Giazzon, 1 Salvatore Perugini.
Replacements: 16 Tommaso D'Apice, 17 Matias Aguero, 18 Dario Chistolini, 19 Emiliano Caffini, 20 Filippo Cristiano, 21 Alberto Chillon, 22 Luciano Orquera, 23 Roberto Quartaroli.
Date: Friday, October 11
Venue: Stade Ernest Wallon
Kick-off: 21.00 local (20.00 GMT)
Referee: Luke Pearce (England)