Stade Français will take on Portuguese opposition on Thursday when they host Lusitanos XV in Paris.
Hooker Aled de Malmanche will captain a Stade team that includes France internationals Jerome Porical and David Attoub.
Former Sharks back Meyer Bosman starts at inside centre, with Australia scrum-half Richard Kingi in the number nine jersey.
Lusitanos XV are the third Portuguese representatives to compete in Europe (after AA Coimbra and Portugal) and they will be searching for a first victory by a Portuguese side in ERC competition.
Four French clubs came up against the Portugal side which entered the tournament in 1998/99 and between them they racked up 306 points.
Stade Français reached the final of this tournament last season winning seven of their nine matches in total.
Stade Français: 15 Jerome Porical, 14 Adrea Cocagi, 13 Geoffrey Doumayrou, 12 Meyer Bosman, 11 Julien Arias, 10 Peter Lydon, 9 Richard Kingi, 8 Nicolas Garrault, 7 Olivier Missoup, 6 Remi Bonfils, 5 Gerhard Mostert, 4 Anton van Zyl, 3 David Attoub, 2 Aled De Malmanche (c), 1 Zurabi Zhvania.
Replacements: 16 Laurent Sempere, 17 Benjamin Chabert, 18 Davit Kubriashvili, 19 Carl Wegner, 20 Pierre Rabadan, 21 Vincent Mallet, 22 Martin Rodriguez, 23 Clement Daguin.
Lusitanos XV: 15 Afonso Rodrigues, 14 Francisco Appleton, 13 Pedro Bettencourt Avila, 12 Luis Miguel Leal, 11 Gonçalo Foro, 10 Pedro Cabral, 9 Francisco Pinto de Magalhães, 8 Vasco Uva (c), 7 Salvador Cunha, 6 Antonio Duarte, 5 Rafael Simoes, 4 Rui D'Orey, 3 Jorge Segurado, 2 Francisco Tavares, 1 João Almeida.
Replacements: 16 Bruno Medeiros, 17 Duarte Foro, 18 Bruno Rocha, 19 Fernando Almeida, 20 Vasco Fragoso Mendes, 21 Antonio Salgueiro, 22 Rodrigo Figueiredo, 23 Luis Salema.
Date: Thursday, 10 October
Venue: Stade Jean Bouin
Kick-off: 20:45 local (18:45 GMT)
Referee: Giuseppe Vivarini (Italy)
Assistant referees: Andrea Spadoni (Italy), Filippo Navarra (Italy)