Kahn Fotuali'i will lead the Ospreys against Toulouse in their Heineken Cup rematch at the Liberty Stadium on Saturday.
Richard Hibbard and Ryan Bevington return to the front row, with Samoa international George Stowers named as a replacement.
The Ospreys hopes of a place in the last eight of the Heineken Cup are hanging by a thread and only a bonus point victory over the most successful side in the tournament will keep those ambitions alive.
Meanwhile, Thierry Dusautoir returns to lead Toulouse for their rematch with the Ospreys on Saturday, replacing Yannick Nyanga at openside flanker.
The French champions continued their impressive record over the Ospreys last weekend with a 30-14 win, stretching their unbeaten run against the Welsh region to three matches.
With Luke McAlister ruled out for a month earlier this week, Jean-Marc Doussain fills in at fly-half alongside Luke Burgess. Maxime Médard starts at full-back, with Yoann Huget moving to the left wing.
19-year-old sensation Gael Fickou also starts, in place of the injured Florian Fritz, whilst in the pack Roman MIllo-Chluski and Vasil Kakovin are also selected.
Ospreys: 15 Richard Fussell, 14 Ross Jones, 13 Andrew Bishop, 12 Ashley Beck, 11 Eli Walker, 10 Dan Biggar, 9 Kahn Fotuali'i (c), 8 Joe Bearman, 7 Justin Tipuric, 6 Ryan Jones, 5 James King, 4 Ian Gough, 3 Campbell Johnstone, 2 Richard Hibbard, 1 Ryan Bevington.
Replacements: 16 Scott Baldwin, 17 Duncan Jones, 18 Adam Jones, 19 Lloyd Peers, 20 George Stowers, 21 Rhys Webb, 22 Matthew Morgan, 23 Tom Isaacs.
Toulouse: 15 Maxime Médard, 14 Vincent Clerc, 13 Yann David, 12 Gael Fickou, 11 Yoann Huget, 10 Jean-Marc Doussain, 9 Luke Burgess, 8 Louis Picamoles, 7 Thierry Dusautoir (c), 6 Jean Bouilhou, 5 Patricio Albacete, 4 Yoann Maestri, 3 Cencus Johnston, 2 Gary Botha, 1 Vasil Kakovin.
Replacements: 16 Jean-Baptiste Poux, 17 Yohan Montes, 18 Roman Millo-Chluski, 19 Yannick Nyanga, 20 Gregory Lamboley, 21 Sébastian Bézy, 22 Yannick Jauzion, 23 Christopher Tolofua.
Date: Saturday, December 15
Venue: Liberty Stadium
Referee: George Clancy (Ireland)