Biarritz took a massive step towards avoiding Top 14 relegation on Saturday with a crucial 15-14 victory over high-flying Clermont.
Toulouse maintained their lead in the standings with a narrow win over Stade FranÃ§ais in Paris.
Bayonne were the big losers of Round 22 as all of their rivals in the relegation battle claimed victory while they lost heavily in Perpignan.
Brive upset a star-studded Toulon side while Lyon kept their survival hopes alive with victory at home to Bordeaux-BÃ¨gles.
Elsewhere, Montpellier moved closer to a home play-off by dominating Agen.
Racing MÃ©tro 27-16 Castres
Biarritz 15-14 Clermont
Brive 14-9 Toulon
Lyon 24-13 Bordeaux-BÃ¨gles
Montpellier 44-18 Agen
Perpignan 47-9 Bayonne
Stade FranÃ§ais 18-22 Toulouse
Biarritz Olympique 15-14 ASM Clermont Auvergne
Parc des Sports d'Aguilera, Biarritz
An enormous victory for Biarritz - their fourth on the trot - as the Basques leap up to tenth in the standings, eight points clear of the drop zone.
That man Dimitri Yachvili was once again the architect of victory for BO, kicking all of his team's points and generally running the show.
The hosts seldom threatened to cross the whitewash but instead looked to occupy territory via the boot.
Clermont led 14-6 at half thanks to tries from Alexandre Lapandry and Benjamin Kayser, but les Jaunards were unable to add to their score in a second period littered by mistakes from both sides.
For Biarritz :
Pens: Yachvili 5
Tries: Lapandry, Kayser
Cons: James 2
Yellow cards: Buttin (Clermont - 55th min)
Biarritz: 15 Iain Balshaw, 14 Taku Ngwenya, 13 Charles Gimenez, 12 Dane Haylett-Petty, 11 Benoit Baby, 10 Julien Peyrelongue, 9 Dimitri Yachvili, 8 Imanol Harinordoquy, 7 Benoit Guyot, 6 Wenceslas Lauret, 5 Pelu Taele-Pavihi, 4 Jerome Thion, 3 Eugene van Staden, 2 Eusebio Guinazu, 1 Yvan Watremez.
Replacements: 16 Romain Terrain, 17 Sylvain Marconnet, 18 Erik Lund, 19 Jean-Baptiste Roidot, 20 Talalelei Gray, 21 Marcelo Bosch, 22 Jean Pascal Barraque, 23 Francisco Gomez Kodela.
Clermont: 15 Lee Byrne, 14 Jean-Marcel Buttin, 13 Aurelien Rougerie, 12 Wesley Fofana, 11 Julien Malzieu, 10 Brock James, 9 Morgan Parra, 8 Julien Bonnaire, 7 Alexandre Lapandry, 6 Julien Bardy, 5 Nathan Hines, 4 Julien Pierre, 3 Vincent Debaty, 2 Benjamin Kayser, 1 Raphael Chaume.
Replacements: 16 Ti'i Paulo, 17 Lionel Faure, 18 Jamie Cudmore, 19 Elvis Vermeulen, 20 Ludovic Radosavljevic, 21 David Skrela, 22 Seru Nakaitaci, 23 Adrien Oleon.
USA Perpignan 47-9 Aviron Bayonnais
Stade AimÃ© Giral, Perpignan
Perpignan's Welsh star James Hook masterminded a crucial 47-9 hammering of their relegation rivals Bayonne to give the 2009 champions some much-needed breathing space.
The 26-year-old was faultless with the boot, kicking four penalties and four conversions and adding a try for good measure for a haul of 25 points that saw the seven-time champions to victory.
Perpignan got off to the start they wanted, storming into a 10-0 lead after just 10 minutes of the game.
Hook contributed five of those points, a penalty and a conversion following the opening try by scrum-half Florian Cazenave, who picked the ball up 20 metres out and squeezed through a narrow gap to cross the line and touch down.
Hook was running the show and went close to scoring a try himself soon after. Having just pulled off a try-saving tackle on Bayonne's lively wing Marvin O'Connor, he chipped ahead and outstripped both compatriot Mike Phillips and former France international Cedric Heymans but the ball just eluded him and trickled over the dead-ball line.
The Welsh fly-half then added two more penalties - either side of a penalty by Bayonne's Jean-Jacques Potgieter - to put the hosts comfortably ahead against a side lacking several stars, including Australian lock Mark Chisholm.
Potgieter reduced the deficit to 16-6 near the half hour as he slotted over a penalty, which needed the aid of the post to go over, and added another shortly before the break to leave them only a converted try behind.
However, Hook made it five out of five successful kicks four minutes into the second half to make it 19-9.
The match swung inexorably Perpignan's way in the 54th minute when flanker Jean-Joseph Marmouyet was sin-binned and a minute later Damien Chouly burrowed over for their second try. Hook converted for 26-9.
Hook crowned a superlative performance by then going over himself and adding the conversion to boot for 33-9.
Perpignan did not let up and a minute after Marmouyet had returned to the action the hosts added another try as Bertrand Guiry touched down - Hook converting - and then South African wing Rudi Coetzee added their sixth try, which was converted by David Mele.
Tries: Cazenave, Chouly, Hook, Guiry, Coetzee
Cons: Hook 4, Coetzee
Pens: Hook 4
Pens: Potgieter 3
Yellow cards: Marmouyet (Bayonne)
Perpignan: 15 Joffrey Michel, 14 Rudi Coetzee 13 David Marty, 12 Maxime Mermoz, 11 Adrien Plante, 10 James Hook, 9 Florian Cazenave, 8 Damien Chouly, 7 Ovidiu Tonita, 6 Bertrand Guiry, 5 Romain Taofifenua, 4 Olivier Olibeau, 3 Nicolas Mas 2 Guilhem Guirado, 1 Kisi Pulu.
Replacements: 16 Charles Geli, 17 Perry Freshwater, 18 Robins Tchale Watchou, 19 Gerrie Britz, 20 David Mele, 21 Nicolas Laharrague, 22 Gregory le Corvec, 23 Benoit Bourrust,
Bayonne: 15 Cedric Heymans, 14 Yoann Huget, 13 Joe Rokocoko, 12 Lionel Mazars, 11 Marvin O'Connor, 10 Jacques Louis Potgieter, 9 Mike Phillips, 8 Marc Baget-Rabarou, 7 Julien Puricelli, 6 Jean Jo Marmouyet , 5 Abdellatif Boutaty, 4 Rob Linde, 3 Neemia Tialata, 2 Francois Da Ros, 1 Victor Manukula
Replacements: 16 David Roumieu, 17 Aretz Iguiniz, 18 Troy Flavell, 19 Guillaume Bernad, 20 Cedric Garcia, 21 Benjamin Boyet, 22 Thibault Lacroix, 23 ClÃ©ment Baiocco.
CA Brive CorrÃ¨ze 14-9 RC Toulon
Stade AmÃ©dÃ©e Domenech, Brive
Like Biarritz, victory for Brive could prove enough to retain their top-flight status.
Brive have built their season around their defence and once again kept a clean sheet.
South African number eight Antonie Claassen try at the end of the first quarter helped the home side to an 8-3 lead at the break.
Jonny Wilkinson's three penalties were the only reply from a lacklustre Toulon side as they searing heat took its toll.
Pens: Belie 3
Pens: Wilkinson 3
Brive: 15 Scott Spedding, 14 Jacques Boussuge, 13 Arnaud Mignardi, 12 Jamie Noon, 11Ronnie Cooke, 10 Mathieu Belie, 9