With just six rounds left of the Top 14 regular season, Perpignan face the threat of dropping into the relegation zone as they visit Clermont on Saturday.
The 2009 champions lie level with fellow giants Biarritz, just four points clear of the drop zone.
Indeed, with the top two places - synonymous with automatic semi-final qualification - all but wrapped up, the intrigue lies at the bottom of the table.
If Lyon fail to get the job done at home against Biarritz, they are almost certain to return to the ProD2.
Bayonne currently occupy the other relegation position but could take a giant step towards safety at home to Brive this weekend.
The battle for play-off places is hotter than ever with Stade FranÃ§ais looking to close the gap on the peleton. They've moved their clash with Agen to Le Mans - a risky move considering the Parisians' woeful record on the road.
The other play-off contenders go head to head this weekend as Castres host Montpellier and Racing visit Toulon in the weekend's biggest clash.
The action starts on Friday when Bordeaux host the leaders hoping for a miracle to avoid being dragged into the scrap for survival below them.
Friday, March 23
Bordeaux-BÃ¨gles v Toulouse
Saturday, March 24
Castres v Montpellier
Clermont v Perpignan
Lyon v Biarritz
Stade FranÃ§ais v Agen
Toulon v Racing MÃ©tro
Bayonne v Brive
Rugby Union betting odds
1 Toulouse 73
2 Clermont 69
3 Toulon 58
4 Montpellier 52
5 Castres 51
6 Racing Metro 49
7 Stade FranÃ§ais 47
8 Agen 44
9 Bordeaux-Begles 37
10 Brive 37
11 Biarritz 34
12 Perpignan 34
13 Bayonne 30
14 Lyon 26
Union Bordeaux-BÃ¨gles v Stade Toulousain
Stade Jacques Chaban-Delmas, Bordeaux
Two teams with very different ambitions kick-off the weekend's action as Toulouse look to consolidate their lead while UBB aim to secure their place in the top flight.
A loss for the hosts will drop them right into the relegation mire and considering that Toulouse won their previous meeting by 50 points, Bordeaux-BÃ¨gles face a tough task as they try to bring a four-game losing streak to an end.
Good news for UBB is that South African scrum-half Heini Adams has passed a late fitness test.
Toulouse have wasted no time in slotting a handful of their returning Six Nations players straight into the starting XV.
Toulouse XV: Jauzion, Matanavou, David, McAlister, Donguy, Beauxis, Doussain, Picamoles, Nyanga, Bouilhou (c), Albacete, Lamboley , Johnston, Servat, Steenkamp.
Replacements: Bregvadze, Human, Millo-Chluski, Galan, Vergallo, Poitrenaud, Fritz, MontÃ¨s
Previous result Toulouse won 56-6 at home
Prediction: The previous meeting between these sides makes the visitors the overwhelming favourites. Toulouse by fifteen points
Kick-off: 20.45 (19.45 GMT)
Referee: Pascal Gauzere
Castres Olympique v Montpellier HR
Stade Pierre Antoine, Castres
Fifth plays fourth with a home play-off the potential prize for the winners.
How things have changed since Rory Kockott kicked all of Castres' points as they won in Montpellier in Round Eight. After a slow start to the season, Montpellier have lost just twice since late November to climb above their hosts this weekend.
Castres have not won in three games but bounced back from a draw with Lyon to almost upset Toulouse a fortnight ago. The next three weeks could make or break the Tarnais' season as they head to play-off rivals Racing and Toulon over the next two weekends.
In contrast to CO, Montpellier have been scoring a lot of tries but have also been conceding a lot of penalties, which is the last thing you want to do against Castres, who are masters of kicking their way to victory.
Previous result: Castres won 21-16 in Montpellier
Prediction: Castres have lost just once at home this season. Castres by six points
Kick-off: 14.15 (13.15 GMT)
Referee: Christophe Berdos
ASM Clermont Auvergne v USA Perpignan
Parc des Sports Marcel Michelin, Clermont Ferrand
Unbeaten at home for two season and unbeaten anywhere since late November, Clermont will look to book a spot in the semi-finals.
Only the very brave - or the crazy - would bet on relegation-threatened Perpignan to end that run after having won on the road just once this season (in Biarritz).
Indeed the Catalans have a very difficult run-in on their hands with home games against Bayonne and Toulouse up next, making even a losing point invaluable to their cause.
As an illustration of their differing fortunes, Clermont have scored 37 tries this season compared to USAP's 20.
Wesley Fofana, AurÃ©lien Rougerie and Julien Bonnaire have been given the weekend off by the Clermont staff, as has USAP prop Nicolas Mas.
Previous result: Clermont 39 -3 in Perpignan
Prediction: We can't see an upset here. Clermont by twelve points
Kick-off: 14.15 (13.15 GMT)
Referee: CÃ©dric Marchat
Lyon Olympique v Biarritz Olympique
Stade Matmut, Lyon
Eight points short of safety, Lyon still have a chance to save their Top 14 hides, but only if they can beat Biarritz on Saturday. With another win possible next week as Bordeaux are set to visit LOU, the hosts will treat this game like a final.
For Biarritz the situation is rather similar except the Basques are coming off the back of two consecutive wins while Lyon haven't tasted success since late December.
With their internationals back in the mix, BO will be looking to make it three wins in a row for the first time this season.
Previous result: 15-all draw in Biarritz
Prediction: Biarritz haven't been great on the road this season but the seem to have finally found some form. Biarritz by a whisker
Kick-off: 14.15 (13.15 GMT)
Referee: Romain Poite
Stade FranÃ§ais Paris v SU Agen
MMArena, Le Mans
Bolstered by the return of their internationals, Stade FranÃ§ais will look to build on the large win over Lyon a fortnight ago and climb back into the play-off places a week before hosting Toulouse in the annual gala in Paris.
The 25 000-seater MMArena in Le Mans is almost sold out as Michael Cheika's team take their 'home' clash out of the capital.
It promises to be a clash of different styles as Stade FranÃ§ais have scored 39 tries to Agen's 20 this season but the Parisians have conceded 43 compared to just 27 by Agen.
Les Agenais still have an outside chance of making the play-offs but with fixtures against Montpellier and