Gloucester captain Luke Narraway is set to make his first appearance of the season against London Irish on Saturday.
Narraway, so often a number eight, will make a rare appearance on the openside flank joining Peter Buxton and Brett Deacon in the back row.
Also back in the matchday squad following absences for various injuries are Dave Lewis and James Simpson-Daniel who are named amongst the replacements.
There's a reshuffle in the midfield where Jonny May partners Henry Trinder but, apart from the afore mentioned changes, it's very much the side that defeated Bath last weekend.
London Irish arrive in good form having attained back to back victories in Aviva Premiership Rugby against Northampton and Newcastle and are going for successive away wins in the Premiership for the first time for twelve months.
The last nine clashes between the two teams in the Premiership have all been won by the home side on the day, whilst London Irish have won only once at Kingsholm in Premiership history: 13-9 on 28 January 2006.
Gloucester Head Coach Bryan Redpath is well aware of the challenge that London Irish will pose on Saturday.
"It'll be tough. London Irish are similar to us. They've had some good games and some where they probably feel they didn't perform so well," he said.
"They'll be pretty fired up coming to Gloucester as there's nothing to lose. I've a lot of time for Toby and Mike Catt and I think it'll be a good contest and not one we should take lightly."
Meanwhile, London Irish have made two changes to the starting line up from the side that beat Newcastle Falcons last weekend.
Max Lahiff and James Sandford come in for Leo Halavatau and Matt Garvey respectively. Faan Rautenbach and Jamie Gibson have returned from injury to be named as replacements.
Form: Gloucester's last eight matches have all been won by the home side on the day. Gloucester have won their last 18 Premiership matches at Kingsholm since Worcester achieved a 13-all draw there in January 2010. London Irish have now attained back to back victories in Aviva Premiership Rugby against Northampton and Newcastle. The Exiles are going for successive away wins in the Premiership for the first time for twelve months. The last nine clashes between the two teams in the Premiership have all been won by the home side on the day, whilst London Irish have won only once at Kingsholm in Premiership history: 13-9 on 28 January 2006.
Gloucester: 15 Olly Morgan, 14 Charlie Sharples, 13 Henry Trinder, 12 Jonny May, 11 Tom Voyce, 10 Tim Taylor, 9 Nick Runciman, 8 Brett Deacon 7 Luke Narraway, 6 Peter Buxton (c), 5 Will James, 4 Tom Savage, 3 Rupert Harden, 2 Darren Dawidiuk, 1 Nick Wood.
Replacements: 16 Matias Cortese, 17 Dan Murphy, 18 Dario Chistolini, 19 David Lyons, 20 Gareth Evans, 21 Dave Lewis, 22 Freddie Burns, 23 James Simpson-Daniel
London Irish: 15 Tom Homer, 14 Topsy Ojo, 13 Jonathan Joseph, 12 Steve Shingler, 11 Adam Thompstone, 10 Dan Bowden, 9 Darren Allinson, 8 Chris Hala'ufia 7 Alex Gray, 6 Bryn Evans, 5 James Sandford , 4 Nick Kennedy, 3 Max Lahiff, 2 David Paice, 1 Clarke Dermody (c)
Replacements: 16 James Buckland, 17 Mark George, 18Faan Rautenbach, 19Declan Danaher, 20 Jamie Gibson, 21 Guy Armitage, 22 Adrian Jarvis, 23 Paul Hodgson
Date: Saturday, October 1
Kick-off: 13.00 (11.00 GMT)
Referee: Greg Garner