Toulouse smashed Biarritz 24-0 on Friday to take provisional lead of the Top 14 standings.
Toulon were unable to score a try in Saint-André's last game at the helm but were easy winners away to Bordeaux-Bègles.
Castres meanwhile ran four tries past Agen to move level with Toulouse and ahead of Clermont and Racing Metro, who meet on Saturday.
Stade Français scored three first-half tries to beat beat Bayonne in the capital.
Elsewhere, Lyon grabbed their first win of the season in Brive leaving Biarritz at the foot of the table.
Montpellier are still win-less after losing narrowly in Perpignan in a real war of attrition.
Bordeaux-Bègles 16-27 Toulon
Brive 12-15 Lyon
Castres 30-11 Agen
Stade Français 33-18 Bayonne
Perpignan 19-12 Montpellier
Toulouse 24-0 Biarritz
To follow on Saturday:
Racing Métro v Clermont
Bordeaux-Bègles 16-27 RC Toulon
Stade André Moga, Bègles
Nine penalties were enough to give Toulon their first win away from home this season and Philippe Saint-André's last as director of RCT before he becomes the French national coach.
Bordeaux scored their first try of the season - the only try of the game - but their indiscipline cost them dearly as Julien Dumora kicked six penalties and Benjamin Lapeyre added two more for the visitors.
The Toulon pack dominated and made sure their side held a 9-3 lead at the break.
Fabien Rofes's late try for the hosts was scant consolation for the Top 14 newcomers.
Bordeaux XV: Reihana - Brana, Rey, Carballo, Connor - Fraser, Adams - Clarkin, Madaule, Purll - Tisseau, Treloar - Decamps, Rofes, Delboulbes
Toulon XV: Rooney ; Lapeyre, Bastareaud, Messina, Smith ; Dumora, Henjak ; El Abd, Armitage, Missoup ; Chesney, Samson ; Hayman, Bruno, Emmanuelli.
CA Brive Corrèze 12-15 Lyon Olympique
Stade Amédée Domenech, Brive
Brive slump to their second loss at home in as many games as LOU claim their first win of the season.
Former Brive fly-half Regis Lespinas was the hero for Lyon as he scored all the visitors' points, including two first-half tries, at his old stomping ground.
LOU led 12-9 at the break with Mathieu Belie landing his fourth penalty to level matters early in the second half.
Lespinas, however, kicked the winner with twelve minutes left on the clock.
Brive XV: Caminati ; Marienval, Cooke, Mignardi, Boussuge ; Bélie, Péjoine ; Bias, Ledévédec, Claasen (cap.) ; Mela, Dubarry ; Cardinali, Lacombe, Laval.
Castres Olympique 30-11 SU Agen
Stade Pierre Antoine, Castres
Castres confirmed their status as one of the form teams of the early season by moving to the top of the standings and handing Agen their first defeat of the season in the process.
Castres scored three tries (by centre Romain Cabannes, number eight Chris Masoe and winger Marc Andreu) to lead 22-3 at half-time.
With ten minutes left, Agen winger Benjamin Petre touched down for the visitors only for Castres winger Pierre-Gilles Lakafia to coast in to ensure the bonus point.
Castres XV: Teulet ; Inigo, Bonnefond, Cabannes, Andreu ; Talès, Kockott ; Caballero, Masoe (cap.), Bornman ; Capo Ortega, Rolland ; Wihongi, Bonello, Coetzee.
Agen XV: Dulin ; Agulla, Ahotaeiloa, Robinson, Petre ; Courrent, Balès ; Giraud, Fonua, Monribot (cap.) ; O'Connor, Lagrange ; Shlekashvili, Janaudy, Cabarry.
Stade Toulousain 24-0 Biarritz Olympique
Stade Ernest Wallon, Toulouse
With leaders Clermont taking on second-placed Racing-Metro on Saturday, Toulouse moved provisionally top while Biarritz are rooted to the bottom of the table.
Former All Black fly-half Luke McAlister played a key role for Toulouse, scoring one of his side's three tries and adding three conversions and a penalty.
It was 3-0 at half time before Toulouse turned on the gas with skipper Yannick Nyanga and Fijian wing Timoci Matanavou scoring before McAlister's try secured the bonus point.
Toulouse XV: Poitrenaud ; Matanavou, David, Jauzion, Donguy ; McAlister, Doussain ; Nicolas, Galan, Nyanga (cap.) ; Maestri, Lamboley ; Falefa, Vernet-Basualdo, Hoeft.
Biarritz XV: Balshaw ; Bolakoro, Gimenez, Burotu, Caprice ; Peyrelongue, Lesgourgues ; Molcard, Faure (cap.), Lauret ; Roidot, Taele ; Buckle, Terrain, Coetzee.
Stade Français Paris 33-18 Aviron Bayonnais
Stade Charléty, Paris
All of Stade Français's tries came in a blistering first-half display with Aussie winger Francis Fainifo crossing in the second minute, number eight Pierre Rabadan adding the second on 12 minutes before Australian fly-half Paul Warwick scored the third in the 23rd minute.
Bayonne scored two tries of their own through scrum-half Marvin O'Connor and wing Garth Ziegler but were generally ouplyaed to trail 24-12 at the break.
The second half was a rather poor affair, leaving Bayonne empty handed after 80 minutes.
Stade Français XV: Rokobaro - Sackey, Turinui, Danty, Fainifo - Warwick, J.Dupuy (cap) - Rabadan, Lyons, Tomiki - Flanquart, van Zyl - Wright, de Malmanche, Slimani
Bayonne XV: Gerber- Ziegler, Lacroix, Visensang, O Connor - Boyet, Audy - Baget Rabarou, Puricelli, Lauaki - Lafitte, Linde - Boyoud, Da Ros, Lafond
USA Perpignan 19-12 Montpellier HR
Stade Aimé Giral, Perpignan
Perpignan get their third (ugly) win in four games while Montpellier as joint-last in the standings, without a single victory.
It wasn't pretty as the Catalan crowd witnessed a true battle. Perpignan took the points, but failed to convince, once again.
USAP led 9-3 at the break before wing Andrien Plante score the only try on the hour mark.
Perpignan XV: Porical - Plante, Cross, Hume, Batlle - Laharrague, Cazenave - Chouly, Perez, Corver - Tchale watchou, Olibeau - Bourrust, Delonca, Freswater
Montpellier XV: Peyras - Bustos Moyano, Combezou, P.Bosch, Audrin, Lagarde, Escande - R.Martin, Tulou, Bost - Privat, Hancke - Jgenti, van Vuuren, Leleimalefaga