Top 14 leaders Toulouse will look to halt their recent slump as they travel to in-form Perpignan before Clermont host Biarritz.
Round 23 offers up a number of heavyweight clashed as Stade FranÃ§ais head to Toulon but the most important match of the weekend could be in Brive, the scene of a do-or-die relegation battle as La Rochelle fight for their top-flight lives.
With just four rounds left of the regular season, the gate is fast closing on the play-offs but nine clubs are still in the race for six places.
Elsewhere, Racing MÃ©tro will be eyeing the championship lead when they visit Bayonne while Castres and Montpellier could take a step closer to the play-offs in Agen and Bourgoin respectively.
Friday, April 1
Perpignan v Toulouse
Saturday, April 2
Bayonne v Racing MÃ©tro
Toulon v Stade FranÃ§ais
Brive v La Rochelle
Bourgoin v Montpellier
Clermont v Biarritz
Agen v Castres
1 Toulouse 69
2 Racing MÃ©tro 68
3 Castres 63
4 Biarritz 62
5 Montpellier 61
6 Clermont 58
7 Perpignan 58
8 Toulon 56
9 Bayonne 54
10 Stade FranÃ§ais 49
11 Agen 38
12 Brive 37
13 La Rochelle 33
14 Bourgoin 5
USA Perpignan v Stade Toulousain
Stade AimÃ© Giral, Perpignan
It's the clash of the weekend as two Heineken Cup quarter-finalists in contrasting form gear up for next week's all-French showdowns.
Coming off the back of five consecutive wins, Perpignan are in great nick ahead of their European clash with Toulon in Barcelona. The Catalans were struggling in the bottom half of the standings a few weeks ago but have made a remarkable comeback and are very much still in race for the play-offs.
Toulouse on the other hand have had a very poor build up to next Sunday's clash with Biarritz. The European champions could only scrape past strugglers Brive at home before being completely outplayed in the drubbing at the hands of Racing last week.
With skipper Thierry Dusautoir out for three weeks, Byron Kelleher still absent and manager Guy NovÃ¨s deciding to rest internationals Vincent Clerc, Maxime MÃ©dard and William Servat, Toulouse will arrive in Catalogne with a below-strength squad.
Good news however is the return from injury of Pumas lock Patricio Albacete and Fijian genius/problem child Rupeni Caucaunibuca.
For the hosts, Perry Freshwater is injured while GrÃ©gory Le Corvec and David Marty are suspended.
Perpignan winger Julien Candelon said joy at his team's bonus-point victory over La Rochelle last week did not last long.
"It's not a relief, it's short-lived happiness," he said.
"A relief is when a goal is achieved and ours is to finish in the top six.
"We'll go into each match like a knock-out game," Candelon said of Perpignan's run-in, which sees them playing direct rivals Racing-Metro, Toulon and Castres after Toulouse.
Previous result: Toulouse won 38-29 at home
Prediction: Considering Perpignan's form and Toulouse's team news, you have to back the hosts. Perpignan by eight points
Kick-off: 20.45 (19.45 GMT)
Aviron Bayonnais v Racing-MÃ©tro 92
Stade Jean Dauger, Bayonne
With four wins in their last five starts, including last week's demolition of leaders Toulouse, Racing-MÃ©tro are clearly a team with momentum.
Another positive result could well see les Ciel et Blanc take the championship lead, but their hosts have plenty to play for.
Bayonne's play-off hopes are hanging by a thread after losing the Basque derby. Given their remaining fixtures, victory is a non-negtoiable but coach Christian Gajan remains upbeat.
"I'm not worried because it was the worst account of ourselves we'd given since the start of the season," he said of the loss to Biarritz.
"I know my players are competitors, that they have a great spirit and that they can rebound."
In the knowledge that they'll have next week off, Racing have named all their big guns including Six Nations Player of the Tournament Andrea Masi at full-back but winger Benjamin Fall is also set to miss the next month through injury.
Former Stormer Joe Pietersen starts at full-back for Bayonne, who welcome back Aretz Iguiniz from suspension.
Previous result: Racing won 15-9 at home
Prediction: It'll be close but Racing are on a roll. Racing Metro by a point or two
Kick-off: 14.30 (13.30 GMT)
RC Toulon v Stade FranÃ§ais
Stade Felix Mayol, Toulon
Like Bayonne, Toulon have no room for error. Last week's defat in Castres has left RCT trailing the pack in the play-offs race. Another defeat and it'll be all over.
Club president Mourad Boudjellal has not been mincing his words this week, and has told his splayers in no uncertain terms that it's time to take responsibility and live up to their lofty salaries.
For Stade FranÃ§ais, the play-offs are a lost cause and their focuss is on preparing for next week's Amlin Challenge Cup quarter-final.
The news in Paris this week has centred (excuse the pun) on Mathieu Bastareaud who is rumours to be on his way to Toulon.
Gevin Henson will start at inside centre for Toulon on debut with Felipe Contepomi set to ride the bench.
Previous result: Stade FranÃ§ais won 22-15 at home
Prediction: Based on motivation levels, there can only be one winner: Toulon by ten points
Kick-off:14.30 (13.30 GMT)
CA Brive CorrÃ¨ze v Stade Rochelais Atlantique
Stade AmÃ©dÃ©e Domenech, Brive
Le match de la peur is essentially a final for La Rochelle as defeat will could very well equal relegation.
Thanks to their bonus-point win over Borugoin last week, Brive have a four-point head start in the scramble to avoid the drop. Four (or five) more will surely be too much for La Rochelle to overhaul.
By the same token, victory for les Maritimes would seriously dent Brive's chances as they must face Biarritz and Montpellier in the coming weeks.
Previous result: La Rochelle won 26-21 at home
Prediction: Brive have found form of late and motivation won't be a problem. Brive by six points
Kick-off:14.30 (13.30 GMT)
CS Bourgoin-Jallieu v Montpellier HR
Stade Pierre Rajon, Bourgoin
A hard-fought yet uninspired victory over Stade FranÃ§ais last week reignited Montpellier's play-offs hopes.
Montpol have never made the knock-out stages in the professional era but a win in the <