Sale Sharks failed to qualify for the Amlin Challenge Cup quarter-finals despite their 54-0 victory over Petrarca at Edgeley Park.
Sale ran in eight tries to secure a comfortable bonus-point win over the Italian minnows in Pool Two, but Brive's victory against Cetransa El Salvador means the Sharks will miss out on a place in the last eight.
Fly-half Rob Miller scored 17 points for Sale, including six conversions and a try, as well as playing a hand in four more.
Chris Brightwell put Sale on track for an emphatic win with the opening try on 11 minutes.
Neil McMillan, Miller and Nick Macleod all crossed to wrap up a bonus point before half-time.
Prop Henry Thomas resumed the scoring after the break on 44 minutes before Will Cliff, Mathew Tait and John Kennedy all crossed to complete the rout, which ended with the hosts facing 14 men following a second yellow card for hooker Agustin Costa Repetto.
However they remain seven points behind Brive with just one game remaining, after former Wales number eight Alix Popham scored the bonus-point try in the 52-3 win over Spaniards El Salvador at Stade Pelouse Amedee-Domenech.
Newcastle Falcons are still waiting for their first win of 2011 after losing 6-0 to Montpellier at Kingston Park, their third defeat of the campaign in Pool Three.
Two penalties in the first half by Benoit Paillaugue were all that separated the teams, but Montpellier's failure to pick up a bonus point has left the door for qualification open for Exeter Chiefs. The top two meet in the final round at Stade Yves du Manoir next week.