With Stade FranÃ§ais running away with Pool Four, even a bonus point win may not be enough to give Leeds Carnegie a realistic chance of finishing top.
The French side dispatched Bucharest Oaks on Thursday, Leeds head into this clash ten points behind the table toppers and without any real chance of turning things around.
The game still holds great meaning for the English though, as they look to avoid the drop in the Aviva Premiership, with developing momentum key to their chances.
Head Coach Neil Back had made four changes for the game, with Ceiron Thomas moving from full-back to fly-half in place of Lachlan McKay. Leigh Hinton replaces Thomas at fifteen.
There are two changes in the front-row, with Phil Swainston and Mike MacDonald replacing Juan Gomez and Gareth Hardy respectively.
Crociati Rugby tbc
Leeds Carnegie 15 Leigh Hinton, 14 Lee Blackett, 13 Henry Fa'afili, 12 Scott Barrow, 11 Michael Stephenson, 10 Ceiron Thomas, 9 Warren Fury, 8 Daniel Browne, 7 Hendre Fourie, 6 Rhys Oakley, 5 Marco Wentzel, 4 Tom Denton, 3 Phil Swainston, 2 Steve Thompson, 1 Mike MacDonald.
Replacements: 16 Phil Nilsen, 17 Gareth Hardy, 18 Gareth Denman, 19 Danny Paul, 20 Alfie To'oala, 21 Scott Mathie, 22 Luther Burrell, 23 Semi Tadulala.
Date: Sunday, December 19
Venue: Stadio XXV AprileReferee: CÃ©dric Marchat (France)
Assistant referees: HervÃ© Dubes (France), Akim Hadj Bachir (France)