Top 14 strugglers La Rochelle will be out to impress as they make their debut in European competition against Rovigo at Stadio Mario Battaglini.
La Rochelle will welcome the break from Top 14 competition as they have managed just two wins from their nine fixtures in the domestic tournament so far this term.
But it won't get any easier fom the French minnows as they travel to a dangerous Rovigo who will be determined to get their campaign off to a winning start.
Rovigo are eager to improve on their last showing in the Amlin Challenge Cup as they suffered heavy defeats to Saracens, Castres and Toulon last season.
Rovigo: 15 Stefan Basson, 14 Marko Stanojevic, 13 Alberto Lunardon, 12 Marcello De Gasperi, 11 Alberto Zorzi, 10 German Bustos, 9 Michele Zanirato, 8 Agustin Guzman, 7 Younes Anouer, 6 Aaron Persico, 5 Jean-FranÃ§ois Montauriol, 4 Tomasso Reato, 3 Massimiliano Ravalle, 2 Luke Mahoney, 1 Rik Dolcetto
Replacements: 16. Flavio Damiano, 17. Giovanni Boccalon, 18. Nicola Quaglio, 19. Daniele Tumiati, 20. NiccolÃ² Badocchi, 22. Francesco Zarattini,
La Rochelle: TBC
Date: Saturday, 9 October
Venue: Stadio Mario Battaglini, Rovigo
Kick-off: 15:00 (14.00GMT)
Referee: Gwyn Morris