The new Top 14 season kicks-off where it left off last June with a rematch between losing finalists Perpignan and champions Clermont.
Friday will see six of the seven Round One fixtures take place before newly-promoted La Rochelle take on last season's surprise package Castres on Saturday.
The action kicks off in Toulouse when the reigning European champions host Agen, who are back in the Top 14 after a three-year stint in the ProD2.
Title hopefuls Toulon will expect to extended last season's unbeaten run at home into this campaign against Bayonne.
Ambitious Racing-MÃ©tro face a tough trip to Brive while Montpellier visit Biarritz.
New Stade FranÃ§ais coach Michael Cheika will expect a winning start to his tenure as Bourgoin travel to the capital.
Friday, August 13
Toulouse v Agen
Toulon v Bayonne
Biarritz Olympique v Montpellier
Brive v Racing-MÃ©tro 92
Stade FranÃ§ais v Bourgoin
Perpignan v Clermont
Saturday, August 14
La Rochelle v Castres
Friday, August 13
Stade Toulousain v SU Agen
Stade Ernest Wallon, Toulouse
A sold-out stadium awaits eight-time champions Agen when they travel to the most successful club in European rugby. Agen last made the final in 2002 and won't be under any illusions that they'll go that far this season.
Toulouse will line-up a mostly French side with Pumas Patricio Albacete and Alberto Vernet Basualdo struggling with knee and shoulder injuries respectively, Fijian wing Vilimoni Delasau out with a hamstring problem, South African loose forward Shawn Sowerby sidelined after a hernia operation and Byron Kelleher still not recovered from his fractured jaw.
That means new Argentine signing Nicolas Vergallo starts in the number nine jersey inside David Skrela in a team stacked with French internationals. Former Bourgoin loose forward Sylvain Nicolas get his first start in red and black.
Agen will also be missing three Fijians: Suspended Rupeni Caucasus has still not returned to France, and newly recruited SaÃ¯moni Vaka and Osea Kolinisau only expected to be fit in September.
A handful of other injuries look set to make Agen's opening day a very tough one.
Prediction: Despite missing a busload of stars, Toulouse should win easily
Kick-off: 18:45 (6:45 GMT)
RC Toulon v Aviron Bayonnais
Stade Felix Mayol, Toulon
Toulon closed their doors on Wednesday to prepare away from prying eyes as the pressure starts to build on a club with lofty ambitions.
Club owner Mourad Boudjellal has labelled his side "favourites" for the Top 14 title and we tend to agree with him. A couple of pre-season wins have suggested things are going the right way.
The hosts will have to do with their first-choice half-back pairing as Pierre Mignoni has pulled out and Jonny Wilkinson has a shoulder injury.
Carl Hayman, George Smith, Rudi Wulf and Paul Sackey all earn their first Toulon caps.
Normal captain Joe Van Niekerk is absent, so the team will be led by Juan Martin Fernandez-Lobbe.
Bayonne won just one game on the road all of last season (in Montpellier) so a trip to fortress Mayol won't be easy.
For the Basques, who are still thanking their lucky stars that Montauban ran out of money, a couple of new faces expected to make a big impact will be missing.
Former Stormers full-back Joe Pietersen (groin) and Bayonne skipper RÃ©my Martin (shoulder) have joined former All Blacks lock Troy Flavell on the sidelines and will miss the season opener.
French international Lionel Mazars starts in midfield with former Bourgoin hero Benjamin Boyet at fly-half.
Results last season: Toulon won both games. 14-8 away and 31-13 at home
Prediction: On paper, the hosts should dominate. Toulon by fifteen points
Kick-off: 19:00 (17:00 GMT)
Referee: CÃ©dric Marchat
Biarritz Olympique v Montpellier HR
Parc des Sports d'Aguilera, Biarritz
Having lost just twice at home last season, Biarritz will start as favourites as they aim for an improved better domestic campaign.
The hosts will be without stalwarts Imanol Harinordoquy (ribs) and Damien Traille (hamstring) with neither expected to be back very soon.
Biarritz have had just one warm-up match ahead of the new season, a 21-7 win over newcomers La Rochelle. Marcelo Bosch starts at full-back with Iain Balshaw in midfield. Wings Takudza Ngwenya and Ilikena Bolakoro have been suspended for disciplinary reasons.
For the visitors, who smashed ProD2 side Carcassonne in preseason, skipper Fulgence Ouedraogo and Benjamin Thierry should be fit to start despite sitting out training earlier this week.
Results last season: Montpellier won 22 - 18 at home; Biarritz won 26 - 10 at home
Prediction: BO are usually reliable at home. Biarritz to win by ten points
Kick-off: 19:00 (17:00 GMT)
Referee: SÃ©bastien Minery
CA Brive CorrÃ¨ze v Racing MÃ©tro 92
Stade AmÃ©dÃ©e Domenech, Brive
Two clubs who spent big money last year but had very different results face off in the Limousin region.
Good news for Racing is that Head Coach Pierre Berbizier has finally not been cited for his outburst against the match officials following his side's loss to Clermont in the play-offs last season.
Bad news however is that Berbizier's team travels South without a number of big names.
Francois Steyn, Andrea Masi, Karim Ghezal and Scott Zimmerman are all still recovering from their injuries. Lionel Nallet has also not been named in the squad nor has Juan Martin Hernandez, who is yet to take contact in training.
Newly-recruited wings Mirco Bergamasco and Benjamin Fall are both expected to start however.
Like last year, the hosts have a very tough draw in the first half of the season, making their opening game at home even more vital.
Brive beat English Premiership champions Leicester 29-17 in preseason but the memory of their home defeat to Racing last season will still be fresh in their minds.
Noises coming out the CABCL have all been positive as they aim to make amends for last year's disappointments that included three losses and two draws at Stade AmÃ©dÃ©e Domenech.
Results last season: Racing won both games: 18-10 away and 25-18 at home.
Prediction: Tough one to call but we'll stick our necks out and back Brive to win by a whisker
Kick-off:19:00 (17:00 GMT)
Referee: Mathieu Raynal