Leicester gave themselves a regular-season shot in the arm after brushing aside Leeds Carnegie 39-6 at Welford Road on Saturday.
Leicester opened the scoring after 12 minutes when Flood, making his first start of the season, kicked a simple penalty.
Leeds hit back almost immediately when the Tigers were penalised at a scrum and Joe Ford hammered over the kick from the touchline.
The visitors then went ahead through another Ford penalty and worse was to follow for Leicester with Lewis Moody sent to the sin bin on the advice of the touch judge.
Despite the loss of Moody, Leicester were able to make it 6-6 when Flood kicked another easy penalty after 24 minutes.
Leicester then had a series of scrums in the visitors' 22 and Leeds were somewhat fortunate not to have a penalty try awarded against them when flanker Calum Clark was sin binned.
The Tigers were also dealt a blow when Tom Croft, their England flanker, was helped off with a leg injury minutes before half-time.
After the restart Leeds were back under pressure when Andy Gomarsall and Erik Lund left the kick off to each other, allowing the Tigers to capitalise.
Another scrummage offence saw the referee lose patience and award a penalty try to Leicester which Flood converted.
Clark returned to the field but it was to no avail as Leicester extended their lead when Flood made a neat break and pass for Jordan Crane to send Scott Hamilton clear before the full-back provided a scoring pass for Anthony Allen.
Tigers went further ahead after 58 minutes when replacement Brett Deacon drove over from close range, Flood converting.
Lote Tuqiri then ran strongly to provide Flood with a comeback try which the fly-half converted.
That proved to be his last action of the game before being substituted after 64 minutes.
Lewis Moody then scored the try of the game by breaking away from a ruck 45 metres out and outpacing the Leeds defence to the line.
Jeremy Staunton converted to complete a miserable second half for the visitors.
Tries: Penalty, Allen, Flood, Deacon, Moody
Con: Flood 3, Staunton
Pen: Flood 2
Leicester: 15 Scott Hamilton,14 Lote Tuqiri, 13 Anthony Allen, 12 Aaron Mauger (capt), 11 Matt Smith, 10 Toby Flood, 9 Ben Youngs, 8 Jordan Crane, 7 Lewis Moody, 6 Tom Croft, 5 Ben Kay, 4 Geoff Parling, 3 Dan Cole, 2 George Chuter, 1 Boris Stankovich.
Replacements: 16 Joe Duffey, 17 Robbie Harris, 18 Jonny Harris, 19 Calum Green, 20 Brett Deacon, 21 James Grindal, 22 Jeremy Staunton, 23 Alesana Tuilagi.
Leeds Carnegie: 15 Leigh Hinton, 14 Richard Welding, 13 Seru Rabeni, 12 Scott Barrow, 11 Lee Blackett, 10 Ceiron Thomas, 9 Andy Gomarsall, 8 Rhys Oakley, 7 Calum Clark, 6 Kearnan Myall, 5 Marco Wentzel (capt), 4 Erik Lund, 3 Pete Bucknall, 2 Vili Ma'asi, 1 Gareth Hardy.
Replacements: 16 Phil Nilsen, 17 Tommy McGee, 18 Phil Swainston, 19 Tom Denton, 20 Jon Pendlebury, 21 Scott Mathie, 22 Joe Ford, 23 Jonny Hepworth.
Referee: JP Doyle
Assistant referees: Robin Goodliffe, Ken Stewart
Television match official: Brian Abrahams