Lyn Jones has handed Gavin Henson his first start in an Ospreys shirt for over six months for the Magners League game against Glasgow at the Liberty Stadium on Sunday.
Henson comes into the side at inside centre and will partner Andrew Bishop, with Mark Taylor dropping out of the squad entirely. Elsewhere in the back line Jonny Vaughton replaces Aled Brew on the left wing.
The only other change in the Ospreys' starting side sees Mike Powell make way for Andy Lloyd in the second row.
Despite having suffered three successive defeats in the Magners League this season Lyn Jones is confident his side can still defend their title successfully.
"I think we can still win the title. We can still make it up as we started last season in the same way," Jones said.
"We've lost three games in a row by a narrow scoreline but we're working hard and we need to keep plugging away.
"Hopefully we can turn things around and it will come our way. It's just the start of a marathon."
Glasgow travel to the Liberty Stadium showing four changes to their side from last week's defeat against Cardiff Blues.
The solitary change in the pack sees James Eddie, who scored as a replacement last week, come in on the flank in the place of Richie Vernon.
"We've brought James Eddie back in who epitomises what we are about here at Glasgow. He is Glasgow through and through and we need the other 14 payers on the field to show the same kind of passion," Glasgow coach Sean Linen said.
The three other changes are in the backs where Colin Shaw replaces the injured Thom Evans and Sam Pinder comes in for Chris O'Young who is also sidelined through injury. The third change sees Hefin O'Hare come back into the fray in place of Max Evans who moves to the bench.
"We need to front-up a bit more. The Welsh teams always give us hard games and facing the league champions is going to be no different. We are preparing for a very tough encounter," added Linen.
Form: The reigning Magners League champions, Ospreys, have made a poor start to their defence slipping to three back to back losses, their worst run of form in the league since 2003-04. The Ospreys have a perfect played 12, won 12 record in home league games against Scottish teams. This game is Glasgow Warriors' third successive away game in the Magners League, where they have suffered defeats are Munster and Cardiff. Glasgow have won just once in their last 19 visits to Wales in all competitions since September 2003: 57-30 over the Scarlets on 9 April 2005. The last three League encounters between Ospreys and Glasgow have been won by the home side on the day.
Ospreys: 15 Lee Byrne, 14 Stefan Terblanche, 13 Andrew Bishop, 12 Gavin Henson, 11 Jonathan Vaughton, 10 Shaun Connor, 9 Justin Marshall, 8 Filo Tiatia (c), 7 Steve Tandy, 6 Tom Smith, 5 Andy Lloyd, 4 Brent Cockbain, 3 Cai Griffiths, 2 Barry Williams, 1 Paul James.
Replacements:16 Richard Hibbard, 17 Andrew Millward, 18 Lyndon Bateman, 19 Ben Lewis, 20 Martin Roberts, 21 Gareth Owen, 22 Aled Brew.
Glasgow: 15 Bernardo Stortoni, 14 Hefin O'Hare, 13 Graeme Morrison, 12 Daryl Gibson, 11 Colin Shaw, 10 Colin Gregor, 9 Sam Pinder, 8 Johnnie Beattie, 7 James Eddie, 6 Stevie Swindall, 5 Alastair Kellock (c), 4 Andy Newman, 3 Moray Low, 2 Eric Milligan, 1 Michael Collins.
Replacements: 16 Pat McArthur, 17 Ed Kalman, 18 Dan Turner, 19 Richie Vernon, 20 Max Evans, 21 Scott Barrow, 22 Calum Forrester.
Date: Sunday September 30, 2007
Kick off: 15:00 BST (14:00 GMT)
Venue: Liberty Stadium, Swansea
Referee: Colin Stanley
Touch judges: Huw Griffiths, Wayne Davies