Munster turned in a complete display at Murrayfield on Friday to thump Edinburgh 9-35 in their Magners League clash.
The result means Edinburgh can't qualify for the Heineken Cup next season, assuming it goes ahead.
They were dealt an instant blow when the Irishmen were handed a controversial seven points from a penalty try.
The home players and fans could only shake their heads in disbelief as Welsh referee Phil Fear ruled they had deliberately hauled down a maul close to the line.
Ronan O'Gara's conversion from dead in front was a formality.
Edinburgh shook off the setback to battle their way back into the contest thanks to two penalties in quick succession by stand-off Phil Godman.
But O'Gara fired one over at the other end to grab back the momentum for the visitors - and he repeated the feat to give his side more breathing space.
Godman completed his penalty treble to give the Gunners fresh hope in the build-up to the interval.
However, there was enough time for O'Gara to notch his own hat-trick with Scotland star Simon Taylor in the sin-bin.
Any prospect of an Edinburgh fight back was snuffed out with a Paul O'Connell try, goaled by dead-eye O'Gara.
Further Munster efforts came from Alan Quinlan and Denis Fogarty.
Pens: Godman 3
Tries: Penalty, O'Connell, Quinlan, Fogarty
Cons: O'Gara 3
Pens: O'Gara 3
Yellow cards: Mick O'Driscoll (Munster - 22nd minute), Simon Taylor (Edinburgh - 38th minute), Brian Carney (Munster - 41st minute)
Edinburgh: 15 Lucio Lopez Fleming, 14 Rob Dewey, 13 Ben Cairns, 12 Matt Dey, 11 Simon Webster, 10 Phil Godman, 9 Greig Laidlaw, 8 Allister Hogg, 7 Alan MacDonald, 6 Simon Taylor, 5 Scott Murray (captain), 4 Alasdair Strokosch, 3 Geoff Cross, 2 Andrew Kelly, 1 Allan Jacobsen.
Replacements: 16 Dougie Hall, 17 Alasdair Dickinson, 18 Fergus Pringle, 19 Ross Rennie, 20 Simon Cross, 21 John Senio, 22 Duncan Hodge.
Munster: 15 Brian Carney 14 Anthony Horgan, 13 Barry Murphy, 12 Lifeimi Mafi, 11 Ian Dowling, 10 Ronan O'Gara, 9 Tomas O'Leary, 8 Anthony Foley (captain), 7 John O'Sullivan, 6 Alan Quinlan, 5 Paul O'Connell, 4 Mick O'Driscoll, 3 Tony Buckley, 2 Frankie Sheahan, 1 Federico Pucciariello.
Replacements: 16 Denis Fogarty, 17 Frank Roche, 18 Denis Leamy, 19 David Wallace, 20 Brian O'Meara, 21 Jeremy Manning, 22 Mossie Lawlor.
Referee: Phil Fear (WRU)
Touch judges: Graham Knox (SRU), Alan Forrest (SRU)