Toulouse and Biarritz will turn their attention to domestic action when they go head to head in the Top 14 on Friday.
Still smarting from their shock European Cup exit, Toulouse will now focus their attention on a third successive French title rather than pursue a consolation European Challenge bid and will want to gain maximum points before dealing with the disruptions that come with the Six Nations fixture clashes.
League leaders Toulon will expect a full house of points at home to stone-last Mont-de-Marsan while second-place Clermont have a much tougher assignment on the road to Perpignan.
In the capital, Stade FranÃ§ais and Grenoble face off for the fourth time this season.
Elsewhere, Montpellier will be looking to put their strong form in Europe into action while Racing Metro have a tricky trip to Bordeaux-BÃ¨gles.
Thursday, January 24
Bayonne v Castres - Preview here
Friday, January 25
Agen v Montpellier
Bordeaux-BÃ¨gles v Racing MÃ©tro
Stade FranÃ§ais v Grenoble
Perpignan v Clermont
Toulon v Mont-de-Marsan
Toulouse v Biarritz
Rugby Union betting odds
1 Toulon 57
2 Clermont 53
3 Toulouse 50
4 Castres 44
5 Grenoble 42
6 Montpellier 41
7 Biarritz 36
8 Racing Metro Paris 34
9 Perpignan 34
10 Stade FranÃ§ais 32
11 Bayonne 26
12 Agen 18
13 Bordeaux-Begles 18
14 Mont-de-Marsan 8
SU Agen v Montpellier HÃ©rault Rugby
Stade Armandie, Agen
After thumping Toulon in Europe last weekend, Montpellier head west looking to consolidate their spot amongst the play-off contenders.
Montpellier were easy winners at home to Agen earlier in the season but came off second best in this fixture last season.
But the hosts are not enjoying the same kind of form as they teeter on the edge of the relegation zone. Indeed, eight consecutive losses have left Agen facing a return to the ProD2.
Agen: 15 Ben Seymour, 14 Saimoni Vaka, 13 Vincent Roux, 12 Senio junior Pelesasa, 11 Nafitalai henry Tuitavake, 10 Conrad Barnard, 9 Mathieu Loree, 8 Opeti Fonua, 7 Marc Giraud, 6 Ueleni Fono, 5 Ross Skeate, 4 Lisiate Faaoso, 3 Gert Muller, 2 Jalil Narjissi, 1 Bernard N nomo,
Replacements: 16 Semisi Telefoni, 17 John Schwalger, 18 Esteban Lozada, 19 Remi Vaquin, 20 Alexi Bales, 21 Jean francois Coux, 22 Silvere Tian, 23 Viliamu Afatia
Montpellier: 15 Martin Bustos Moyano, 14 Timoci Nagusa, 13 Thomas Combezou, 12 Shontayne Hape, 11 Yoan Audrin, 10 Francois Trinh-Duc, 9 Julien Tomas, 8 Alex Tulou, 7 Mamuka Gorgodze, 6 Alexandre Bias, 5 Thibaut Privat, 4 Mickael De marco, 3 Maximiliano Bustos, 2 Agustin Creevy, 1 Mikheil Nariashvili.
Replacements: 16 Erasmus Jansen van vuuren, 17 Yvan Watremez, 18 Alikisio Fakate, 19 John Beattie, 20 Benoit Paillaugue, 21 Paul Bosch, 22 Benjamin Thiery, 23 Barry Faamausili.
Previous result: Montpellier won 32-15
Prediction: Montpellier's current form makes them favourites. Montpellier by six points.
Kick-off: 19.00 (18.00 GMT)
Referee: Mathieu Raynal
Union Bordeaux-BÃ¨gles v Racing MÃ©tro 92
Stade AndrÃ© Moga, BÃ¨gles
Two teams in desperate need of points - for very different reasons - clash on the west coast. UBB have been stuck in the relegation zone for three rounds and need to start cashing in on their fixtures at home, where they haven't won since Round 5.
After a very poor autumn, Racing seem to have found some form as their shock win over Toulon in Round 15 was the first time they've scored consecutive wins since September.
Racing gave Saracens a real test in Europe before resting most of their first XV for last week's loss away to Munster, so the Parisians will arrive fresh.
Seven points off the pace in the play-offs race, a positive result is a non-negotiable for Racing.
Bordeaux-BÃ¨gles: 15 Bruce Reihana, 14 Metuisela Talebulamaijaina, 13 Julien Rey, 12 Andrew Mailei, 11 Felix Le bourhis, 10 Camille Lopez, 9 Heini Adams, 8 Justin Purll, 7 Matthew Clarkin, 6 Louis benoit Madaule, 5 Adam Jaulhac, 4 Cameron Treloar, 3 Silviu Florea, 2 Wayne Avei, 1 Laurent Delboulbes,
Replacements: 16 Hikairo Forbes, 17 Jefferson Poirot, 18 Francois Tisseau, 19 Gautier Gibouin, 20 Baptiste Serin, 21 Lachie Munro, 22 Rafael Carballo, 23 Albert Toetu
Racing MÃ©tro:15 Juan Martin Hernandez, 14 Benjamin Fall, 13 Guillaume Bousses, 12 Alexandre Dumoulin, 11 Juan Imhoff, 10 Jonathan Wisniewski, 9 Maxime Machenaud, 8 Jacques Cronje, 7 Bernard Le roux, 6 Camille Gerondeau, 5 Manuel Carizza, 4 Francois Van der Merwe, 3 Luc Ducalcon, 2 Benjamin Noirot, 1 Julien Brugnaut.
Replacements: 16 Thomas Bianchin, 17 Eddy Ben Arous, 18 Jone Qovu, 19 Alvaro Galindo, 20 Henry Chavancy, 21 Olly Barkley, 22 Fabrice Metz, 23 Juan pablo Orlandi.
Previous result: Racing won 18-7
Prediction: Last year UBB won this fixure 22-18 but Racing seem to be hitting some form. Racing by a whisker.
Kick-off: 19.00 (18.00 GMT)
Referee: Romain Poite
Stade FranÃ§ais Paris v FC Grenoble
Stade CharlÃ©ty, Paris
These sides meet for the fourth time this season after clashing in the same Amlin Challenge Cup pool, which Stade FranÃ§ais won.
In the three previous games, the respective home side has always come out on top. Form suggests that trend should continue as Grenoble, although unbeaten at home, have not won on the road since Round 1 in Bordeaux.
Stade FranÃ§ais meanwhile have yet to fall at Stade CharlÃ©ty this term and will be eyeing a place in the top half of the standings.
Stade FranÃ§ais: 15 Hugo Bonneval, 14 Paul Williams, 13 Geoffrey Doumayrou, 12 Morgan Turinui, 11 Jeremy Sinzelle, 10 Paul Warwick, 9 Julien Dupuy, 8 David Lyons, 7 Antoine Burban, 6 Olivier Missoup, 5 Pascal Pape, 4 Alexandre Flanquart, 3 David Attoub, 2 Laurent Sempere, 1 Aled De malmanche,
Replacements: 16 Remi Bonfils, 17 Rabah Slimani, 18 Anton Van zyl, 19 Sergio Parisse, 20 Jerome Fillol, 21 Francis Fainifo, 22 Jerome Porical, 23 Stanley Wright
Grenoble: 15 Joaquin Tuculet, 14 Matthieu Nicolas, 13 Rida Jaouher, 12 Rudolf Coetzee, 11 Viliame Waqaseduadua, 10 Nicolas Laharrague, 9 Jonathan Pelissie, 8 Richard Sowerby, 7 Henry Vanderglas, 6 Jonathan Best, 5 Naude Beukes, 4 Benjamin Hand, 3 Dayna Edwards, 2 Anthony Hegarty, 1 Kenan Mutapcic.
Replacements: 16 Gregory Fabro, 17 Albertus Buckle, 18 Andrew Farley, 19 Florian Faure, 20 Fabien Alexandre, 21 Aloisio Butonidualevu, 22 Clement Darbo, 23 Feliuaki Taukeiaho.
Previous result: Grenoble won 26-12