Top 14 leaders and Heineken Cup title contenders Clermont will head to Castres on Friday without a handful of injured internationals.
Les Jaunards, who open their European campaign against Treviso next week, have been hit by a string of injuries with centre Aurelien Rougerie and wing Napolioni Nalaga both sidelined for this weekend, the club confirmed.
Captain Rougerie is still suffering from a back injury he picked up during a 44-20 win over Grenoble two weeks ago, while Nalaga is rested after receiving a knock to his ribs during Friday's 28-25 victory over Stade Franšais.
French international scrum-half Morgan Parra will also be missing as he is due for a break after competing in 505 of the 560 minutes played by the team since the beginning of the season.
Prop Vincent Debaty (leg) and lock Jamie Cudmore (thigh) are also doubtful.
Good news, however, for fans in the Auvergne is the return of South African flanker Gerhard Vosloo, who has been out since last April after a groin operation.