Samoa have named a line-up missing Census Johnston, Alesana Tuilagi and Maurie Fa'asavalu for their clash with Ireland at Aviva Stadium on Saturday.
Gavin Williams, David Lemi and Dan Leo are also missing from the islanders' squad this weekend.
Williams' absence means scrum-half Kahn Fotuali'i will lead coach Stephen Betham's side.
Meanwhile, the loss of Toulouse's Johnston to injury means Leicester's loosehead Logovi'i Mulipola wears three against Jack McGrath.
The Irish Rugby Football Union has confirmed a minute's silence before kick off to mark the death of legendary Samoan player Peter Fatialofa.
Samoa: 15 Faatoina Autagavaia, 14 Alapati Leuia, 13 George Pisi, 12 Johnny Leota, 11 Brando Vaaulu, 10 Tusi Pisi, 9 Kahn Fotuali'i, 8 Taiasina Tuifua, 7 Jack Lam, 6 Ofisa Treviranus, 5 Teofilo Paulo, 4 Faatiga Lemalu, 3 Logovi'i Mulipola, 2 Ole Avei, 1 Sakaria Taulafo.
Replacements: 16 Tii Paulo, 17 Viliamu Afatia, 18 James Johnston, 19 Joe Tekori, 20 Alafoti Faosilivia, 21 Jeremy Sua, 22 Isaia Tuifua, 23 Fautua Otto.
Date: Saturday, November 9
Kick-off: 17:45 GMT
Venue: Aviva Stadium, Dublin
Referee: Steve Walsh (Australia)
Assistant referees: Wayne Barnes (England), Luke Pearce (England)
Television match official: Carlo Damasco (Italy)
Assessor: Lyndon Bray (SANZAR)