Scotland have been hit by a double blow following their physical clash with the Boks after Ryan Wilson and Peter Horne suffered tour-ending injuries.
The Glasgow pair sustained shoulder and knee injuries in the loss and follow Pat MacArthur, Kelly Brown and Geoff Cross in returning home.
"The three most significant injuries from yesterday involved Peter Horne, Ryan Wilson and Ruaridh Jackson," said Scottish Rugby's lead physiotherapist, Paul McGinley.
"Peter's knee injury will rule him out for the rest of the tour and he will return home for further investigation and follow-up. Likewise for Ryan with his shoulder injury.
"As far as Ruaridh is concerned, he suffered a blow to his shoulder and he will remain with us for on-going treatment this week.
"As ever, with an international match of this magnitude, a number of other players have reported to us with knocks and bumps .
"Steve Lawrie, who was unable to be involved yesterday, is improving following the back pain he experienced last week."
Scotland have yet to make a decision on whether any reinforcements will join the squad.