London Irish wing Marland Yarde will win his first England cap against Argentina this weekend in Buenos Aires.
The 21 year-old comes into the side on the left wing to face the Pumas at Velez Sarsfield on Saturday.
Bath's Kyle Eastmond, who made his Test debut in last Saturday's 32-3 win in Salta, will start for the first time in the number 12 shirt vacated by Lions-bound centre Billy Twelvetrees.
And fly-half Stephen Myler will win a first cap if he comes off the replacements' bench.
England are bidding to secure a first series win in Argentina since 1981, when Bill Beaumont's tourists drew the first and won the second of their two Tests.
"It is great to reward young players who have pushed through this season. They have worked hard to earn their opportunities on this tour," said England head coach Stuart Lancaster.
"This is a young England side which made a very positive start to the series in Salta. But we expect Argentina to come back very strongly in front of a big home crowd. It's a great challenge and one we are all looking forward to."
England: 15 Mike Brown, 14 Christian Wade, 13 Jonathan Joseph, 12 Kyle Eastmond, 11 Marland Yarde, 10 Freddie Burns, 9 Lee Dickson, 8 Ben Morgan, 7 Matt Kvesic, 6 Tom Wood (c), 5 Dave Attwood, 4 Joe Launchbury, 3 David Wilson, 2 Rob Webber, 1 Joe Marler.
Replacements: 16 David Paice, 17 Paul Doran Jones, 18 Henry Thomas, 19 Courtney Lawes, 20 Billy Vunipola, 21 Richard Wigglesworth, 22 Stephen Myler, 23 Ben Foden.
Date: Saturday, June 15
Venue: Velez Sarsfield, Buenos Aires
Kickoff: 16:10 local (20:10 BST)
Referee: Nigel Owens (Wales)
Assistant referees: Marius Jonker (South Africa), Christie du Preez (South Africa)
TMO: Shaun Veldsman (South Africa)
Assessor: Carlos Molinari (Argentina)