England have named 11 uncapped players in their squad for the Barbarians game and three-match tour to Uruguay and Argentina.
They are forwards Rob Buchanan (Harlequins), Calum Clark (Northampton Saints), Matt Kvesic (Worcester Warriors), Ed Slater (Leicester Tigers), Henry Thomas (Sale Sharks) and Billy Vunipola (London Wasps), and backs Kyle Eastmond (Bath Rugby), Jonny May (Gloucester Rugby), Joel Tomkins (Saracens), Christian Wade (London Wasps) and Marland Yarde (London Irish).
England - minus the players from the Aviva Premiership final the previous day - are taking on the Barbarians at Twickenham Stadium on May 26 before playing a CONSUR XV, representing the South American nations, in Montevideo, Uruguay, on June 2, and then Tests against Argentina in Salta (June 8) and Buenos Aires (June 15).
Captained by Northampton Saints' Tom Wood, the group includes five players who are 21 or under, the youngest of whom is London Wasps number eight Billy Vunipola, who represented England Under 20s last year.
"We're really looking forward to this tour and we've selected a young and exciting side which I'm sure will do the country proud in a tough series of matches," said England Head Coach Stuart Lancaster.
"The key principles in selection were threefold: first and foremost to win the games but also to develop strength in depth and more options in certain positions, and to give one or two players a physical and mental break.
"We feel we've got the balance right and have given places to a number of players who have shone in the Aviva Premiership this season, one or two who have been on the fringes for a while, and several players who have been involved over the last year or so. This is everyone's chance to step up.
"Tom Wood will captain the side and I am sure he will do a fantastic job, as he has the respect of all the players and management and we are looking forward to other leaders developing in the absence of some senior players.
"A few are being rested after a hard campaign but they will, of course, be considered by the British and Irish Lions should they be required."
Players rested include Chris Robshaw, Danny Care (both Harlequins), Toby Flood (Leicester Tigers), Brad Barritt and Chris Ashton (both Saracens).
Anthony Allen (Leicester Tigers) and James Haskell (London Wasps) were not considered on medical grounds.
Forwards: Dave Attwood, Rob Buchanan, Calum Clark, Alex Corbisiero, Paul Doran Jones, Tom Johnson, Matt Kvesic, Joe Launchbury, Courtney Lawes, Joe Marler, Ben Morgan, David Paice, Ed Slater, Henry Thomas, Billy Vunipola, Rob Webber, David Wilson, Tom Wood (c).
Backs: Mike Brown, Freddie Burns, Lee Dickson, Kyle Eastmond, Ben Foden, Alex Goode, Jonathan Joseph, Jonny May, David Strettle, Joel Tomkins, Billy Twelvetrees, Christian Wade, Richard Wigglesworth, Marland Yarde.