England fly-half Toby Flood has been ruled out of Saturday's match against New Zealand due to a broken toe.
Flood was substituted in the second half of last Saturday's loss to South Africa by Owen Farrell, but was also temporarily replaced in the first half and missed two crucial kicks at goal.
The Leicester stalwart's injury is not as bad as initially expected, but it will prevent him from recovering in time for the game against the All Blacks.
England's most capped current player with 54 caps, Flood will now be replaced on Saturday by either Farrell or Gloucester fly-half Freddie Burns, who was called up to the squad on Sunday as injury cover.
The other major concern for Stuart Lancaster is prop Alex Corbisiero who picked up a knee injury against South Africa, but there is no word yet on whether he will be ruled out of Saturday's game.