Joe Launchbury will start his first Test for England in Saturday's November International against South Africa at Twickenham.
The 21-year-old London Wasps lock has impressed off the bench against Fiji and Australia and gets his chance in a side showing six changes.
Tom Wood and Ben Morgan take over from Tom Johnson and Thomas Waldrom at flank and number eight respectively, while Alex Corbisiero comes in for Joe Marler at loosehead prop.
Mike Brown replaces Charlie Sharples on the left wing and Ben Youngs partners Leicester Tigers' team-mate Toby Flood at halfback.
There are also call-ups to the bench for the first time in this series for James Haskell, Mouritz Botha and Jonathan Joseph.
"We have picked a team that will give us the best chance of beating South Africa," said England head coach Stuart Lancaster.
"There were some tight calls, which is what you want as coaches, but the players we have brought into start have been training well, will bring a real motivation to make the most of their opportunity and will suit the challenge we face against a tough and physical South African team."
England: 15 Alex Goode, 14 Chris Ashton, 13 Manu Tuilagi, 12 Brad Barritt, 11 Mike Brown, 10 Toby Flood, 9 Ben Youngs, 8 Ben Morgan, 7 Chris Robshaw (c), 6 Tom Wood, 5 Geoff Parling, 4 Joe Launchbury, 3 Dan Cole, 2 Tom Youngs, 1 Alex Corbisiero.
Replacements: 16 David Paice, 17 David Wilson, 18 Mako Vunipola, 19 Mouritz Botha, 20 James Haskell, 21 Danny Care, 22 Owen Farrell, 23 Jonathan Joseph.
Date: Saturday 24 November
Venue: Twickenham Stadium, London
Kick-off: 14:30 GMT (16:30 SA time)
Referee: Nigel Owens (Wales)
Assistant referees: Glen Jackson (New Zealand), Peter Fitzgibbon (Ireland)
Television match official: Jim Yuille (Scotland)