There's an all-Premiership clash on Friday's Challenge Cup fixture card as Sale Sharks welcome Worcester Warriors to Manchester.
Josh Watkins will make his Warriors debut, with the 19-year-old winger among 11 changes Director of Rugby Dean Ryan makes to the starting team that played London Irish last weekend.
Fellow academy youngsters Ben Howard and Max Stelling will both feature in the side after signing first-team contracts for next season earlier this week.
Josh Matavesi and Jonny Arr, who both came on as replacements last weekend, return to the starting line-up after spells on the sidelines with injury.
The forward pack sees a reshuffle with Jeremy Becasseau, Ed Shervington and John Andress named in the front-row.
Dean Schofield, who will captain the side, is recalled to the second-row alongside Mike Williams, while Chris Jones is given a starting berth in the back-row.
"The Challenge Cup is an opportunity for some of the youngsters to get involved. We've done that right from the first game and we will do that again over this period," said Ryan.
"We'll look to utilise these guys again over the next three or four weeks to see if they have grown from their experiences.
"Sometimes growing youngsters can be difficult because sometimes they get thrust in and it's difficult to learn, especially in an environment that isn't as successful as we would like it to be."
Meanwhile, Sale name a strong line-up that includes fly-half Danny Cipriani in the pivot position; keen to boost his chances of England involvement in the coming months.
Cipriani is partnered by Welsh scrum-half Dwayne Peel, who announced earlier this week he is to leave the club at the end of the season to link up with Andy Robinson at Bristol.
Powerful ex-All Black Sam Tuitupou is named at inside centre, with another former New Zealand international - Dan Braid - skippering the side from the blindside flank.
Sale Sharks: 15 Rob Miller, 14 Tom Brady, 13 Johnny Leota, 12 Sam Tuitupou, 11 Mark Cueto, 10 Danny Cipriani, 9 Dwayne Peel, 8 James Gaskell, 7 David Seymour, 6 Dan Braid (c), 5 Michael Paterson, 4 Jon Mills, 3 Henry Thomas, 2 Marc Jones, 1 Eifion Lewis-Roberts.
Replacements: 16 Tommy Taylor, 17 Ross Harrison, 18 Vadim Cobilas, 19 Andrei Ostrikov, 20 Mark Easter, 21 Will Cliff, 22 Nick MacLeod, 23 Tom Arscott.
Worcester Warriors: 15 Ben Howard, 14 Josh Drauniniu, 13 Max Stelling, 12 Josh Matavesi, 11 Josh Watkins, 10 Paul Warwick, 9 Jonny Arr, 8 Leonardo Senatore, 7 Richard De Carpentier, 6 Chris Jones, 5 Mike Williams, 4 Dean Schofield (c), 3 John Andress, 2 Edd Shervington, 1 Jeremy Becasseau.
Replacements: 16 Nick Seymour, 17 George Porter, 18 Rob O'Donnell, 19 James Percival, 20 Sam Betty, 21 Paul Hodgson, 22 Ignacio Mieres, 23 Ravai Fatiaki.
Date: Friday 10th December
Kick-off: 2000 GMT
Referee: David Wilkinson (Ire)
Bordeaux-Begles v Mogliano
Bordeaux-Begles: 15 Joaquim Tuculet, 14 Rafael Carballo, 13 Charles Brousse, 12 Thibault Lacroix, 11 Robert Lilomaiava, 10 Romain Lonca, 9 Baptiste Serin, 8 Marco Tauleigne, 7 Poutasi Luafatu, 6 Gauthier Gibouin, 5 Adam Jaulhac, 4 Cameron Treloar (c), 3 Patrick Toetu, 2 Benat Auzqui, 1 Jefferson Poirot.
Replacements: 16 Jean-Charles Fidinde, 17 Laurent Delboulbes, 18 Zaza Navrozashvili, 19 Matthew Graham, 20 Louis Madaule, 21 Manu Saubusse, 22 Gilem Queheille, 23 Jean-Baptiste Lamotte.
Mogliano: 15 Nicolo' Fadalti, 14 Marco Gazzola, 13 Giovanni Benvenuti, 12 Tommaso Boni, 11 Filippo Guarducci, 10 Matt Cornwell, 9 Edoardo Padovani, 8 Meyer Swanepoel, 7 Marco Lazzaroni, 6 Andrea Ceccato (c), 5 Federico Maso, 4 Enrico Pavanello, 3 Simone Ferrari, 2 Ivan Gianesini, 1 Davide Meggetto.
Replacements: 16 Ornel Gega, 17 Derrick Appiah, 18 Alessio Ceglie, 19 Andrea Trotta, 20 Thorleif Halvorsen, 21 Jacopo Bocchi, 22 Enrico Bacchin, 23 Ezio Galon.
Date: Friday 10th January
Kick-off: 1930 local, 1830 GMT
Referee: Ian Tempest (Eng)