Bayonne have made a number of changes to the side that went down 34-6 at Bordeaux-Begles for the visit of Grenoble on Thursday.
The side for Amlin Challenge Cup clash features Scott Spedding moving from fly-half to full-back, and Stephen Brett named in the pivot position.
Elsewhere in the backline, Bastian Fuster moves from wing to partner Sam Gerber at inside centre, with Joe Rokocoko missing out on selection. With Spedding named at full-back, Martin Bustos Moyano shifts to the right wing.
Mike Phillips is replaced at scrum-half by Mathieu Belie.
In the forwards, a new front-row is named, with Aretz Iguiniz, Gregory Arganese and Gert Muller starting. At second-row, Lisiate Faaoso is replaced by Abdellatif Boutaty to partner captain Mark Chisolm.
A new back-row is also given the nod for the fixture, with Guillaume Bernard, Jean-Jo Marmouyet and Dwayne Haare starting in place of Jean Monribot, Julien Puricelli and Opeti Fonua.
Meanwhile, from the Grenoble backline that started in last week's victory over Racing Metro last weekend, Geoffroy Messina switches from outside to inside centre, with Rida Jaouher wearing the number thirteen jersey.
Ratu Ratini moves from left to right wing, with Daniel Kilioni starting on the left, and Benjamin Thiery dropped altogether.
Half-back pairing James Hart and Olly Barkley are replaced by Nicolas Bezy and Jordan Michallet.
In the pack, Flavien Nouhaillaguet comes in at number eight, with Fabien Alexandre moving to blindside flanker, and Benjamin Hand dropped. Thibault Rey replaces Naude Beukes to partner Hendrik Roodt at second-row, while the front row sees a new trio of Kenan Mutapic, Florian Lescadieu and Richard Choirat start.
Bayonne: 15 Scott Spedding, 14 Martin Bustos Moyano, 13 Sam Gerber, 12 Bastien Fuster, 11 Marvin O'Connor, 10 Stephen Brett, 9 Mathieu Belie, 8 Dwayne Haare, 7 Jean-Jo Marmouyet, 6 Guillaume Bernad, 5 Mark Chisholm (c), 4 Abdellatif Boutaty, 3 Gert Muller, 2 Gregory Arganese, 1 Aretz Iguiniz.
Replacements: 16 David Roumieu, 17 JC Van Rensburg, 18 Vitolio Manukula, 19 Lisiate Fa'aoso, 20 Opéti Fonua, 21 Jean Monribot, 22 Mike Phillips, 23 Matthieu Ugalde.
Grenoble: 15 Fabien Gengenbacher (c), 14 Ratu Alipate Ratini, 13 Rida Jaouher, 12 Geoffroy Messina, 11 Daniel Kilioni, 10 Jordan Michallet, 9 Nicolas Bezy, 8 Flavien Nouhaillaguet, 7 Fabien Alexandre, 6 Cedric Beal, 5 Hendrik Roodt, 4 Thibault Rey, 3 Richard Choirat, 2 Florian Lescadieu, 1 Kenan Mutapcic.
Replacements: 16 Vincent Campo, 17 Romain David, 18 Kevin Goze, 19 Geoffrey Nouhaillaguet, 20 James Hart, 21 Shane O'Leary, 22 Louis Marrou, 23 Roland Bernard.
Date: Thursday, 10 October
Venue: Stade Jean-Dauger
Referee: Marius Mitrea (Italy)
Assistant referees: Stefano Penne (Italy), Stefano Traversi (Italy)
TMO: Alan Falzone (Italy)