Wales international James Hook will direct Perpignan from fly-half in their Amlin Challenge Cup quarter-final meeting with Toulouse on Friday.
USAP have named their strongest available line-up for the European clash while Toulouse are missing key quartet Thierry Dusautoir, Yannick Nyanga, Louis Picamoles and Luke McAlister.
Perpignan are currently seventh in the Top 14, six points off the play-off spots while Toulouse are sitting in third position ahead of the run-in.
Toulouse, who are also missing prop Census Johnston, have named Vasil Kakovin in his place while the back-row trio is Gillian Galan, Sylvain Nicolas and Grégory Lamboley. Luke Burgess and Lionel Beauxis are the half-backs.
Perpignan's pack meanwhile is one of real strength as Henry Tuilagi, Alasdair Strokosch and Dan Leo are behind second-rows Romain Taofifenua and Sebastien Vahaamahina.
The front-row, which has loosehead prop Sona Taumalolo on the bench, sees Nicolas Mas, Guilhem Guirado and Sebastien Taofifenua pack down as starters at Stade Aimé Giral.
Perpignan: 15 Gavin Hume, 14 Farid Sid, 13 Lifeimi Mafi, 12 Sione Piukala, 11 Adrien Plante, 10 James Hook, 9 Florian Cazenave, 8 Henry Tuilagi, 7 Alasdair Strokosch, 6 Dan Leo, 5 Romain Taofifenua, 4 Sebastien Vahaamahina, 3 Nicolas Mas, 2 Guilhem Guirado, 1 Sebastien Taofifenua.
Replacements: 16 Romain Terrain, 17 Sona Taumalolo, 18 Kisi Pulu, 19 Guillaume Vilaceca, 20 David Mele, 21 Sofiane Guitoune, 22 Bertrand Guiry, 23 Luke Narraway.
Toulouse: 15 Maxime Medard, 14 Timoci Matanavou, 13 Florian Fritz, 12 Gaël Fickou, 11 Yves Donguy, 10 Lionel Beauxis, 9 Luke Burgess, 8 Gillian Galan, 7 Sylvain Nicolas, 6 Grégory Lamboley, 5 Edwin Maka, 4 Romain Millo-Chluski, 3 Vasil Kakovin, 2 Jaba Bregvadze, 1 Jean-Baptiste Poux.
Replacements: 16 Christopher Tolofua, 17 Cyril Baille, 18 Yohan Montes, 19 Ruslan Boukerou, 20 Karl Chateau, 21 Yannick Jauzion, 22 Yann David, 23 Sebastien Bezy.
Date: Friday, April 5
Kick-off: 21:00 local (20:00 BST)
Venue: Stade Aimé Giral
Referee: Alain Rolland (Ireland)
Assistant referees: Greg Garner (England), Luke Pearce (England)