Italy coach Jacques Brunel will hand former Scotland under-20 player Tommaso Allan his full debut when the Azzurri host Argentina in the third and final test of their November series on Saturday.
Italy-born Allan, who has made substitute appearances for Italy after being drafted into the squad last month, is one of three changes for the clash against the Pumas at the Olympic Stadium.
The 20-year-old Perpignan replaces Luciano Orquera, who drops to the bench, with Michele Campagnaro starting at outside centre in place of veteran Gonzalo Canale.
Canale moves to inside centre to replace Luca Morisi, who has been sidelined since last week having suffered a heavy tackle early in a 37-31 win over Fiji which required him to have his spleen removed.
Robert Barbieri comes back into Brunel's starting XV at openside flanker, replacing Mauro Bergamasco who is not included in the matchday squad.
Both number eight and captain Sergio Parisse and prop Martin Castrogiovanni will start, meaning the pair will pick up their 101st caps for Italy to pull level with retired scrum-half Alessandro Troncon.
Retired prop Andrea Lo Cicero holds the record for Italy's most caps on 103.
Italy 15 Luke McLean, 14 Giovambattista Venditti, 13 Michele Campagnaro, 12 Gonzalo Canale, 11 Tommaso Iannone, 10 Tommaso Allan, 9 Edoardo Gori, 8 Sergio Parisse (c), 7 Robert Barbieri, 6 Alessandro Zanni, 5 Valerio Bernabo, 4 Quintin Geldenhuys, 3 Martin Castrogiovanni, 2 Leonardo Ghiraldini, 1 Michele Rizzo.
Replacements: 16 Davide Giazzon, 17 Matias Aguero, 18 Lorenzo Cittadini, 19 Marco Bortolami, 20 Joshua Furno, 21 Tobias Botes, 22 Luciano Orquera, 23 Tommaso Benvenuti.
Date: Saturday, November 23
Venue: Stadio Olimpico, Rome
Kick-off: 15.00 local (14.00 GMT)
Referee: Chris Pollock (New Zealand)