Treviso fly-half Alberto Di Bernardo will make his Test debut for Italy in Saturday's clash with South Africa at Kings park in Durban.
Di Bernardo is the only new cap in the Azzurri matchday 23 as he takes over from Luciano Orquera, who drops to the bench having been the first choice fly-half during Italy's strong Six Nations campaign.
Former skipper Marco Bortolami returns to the second row after a year out following a shoulder injury.
In total there are eight changes to the team that beat Ireland in March including a revamped midfield featuring youngsters Luca Morisi and Alberto Sgarbi.
Italy: 15 Andrea Masi, 14 Giovanbattista Venditti, 13 Luca Morisi, 12 Alberto Sgarbi, 11 Luke Mclean, 10 Alberto Di Bernardo, 9 Edoardo Gori, 8 Sergio Parisse (captain), 7 Robert Barbieri, 6 Alessandro Zanni, 5 Marco Bortolami, 4 Antonio Pavanello, 3 Lorenzo Cittadini, 2 Leonardo Ghiraldini, 1 Alberto De Marchi
Replacements: 16 Davide Giazzon, 17 Matias Aguero, 18 Martin Castrogiovanni, 19 Valerio Bernabo, 20 Joshua Furno, 21 Tobias Botes, 22 Luciano Orquera, 23 Tommaso Iannone
Date: Saturday, June 8
Venue: Kings Park, Durban
Kick-off: 17.15 (15.15 GMT)
Weather: 27° C. SunnyReferee: Pascal Gauzčre (France)
Assistant referees: Nigel Hennessy (Wales), Blake Beattie (South Africa)