Argentina centre Juan Martín Hernández has been ruled out his country's match against South Africa at Loftus Versfeld in Pretoria.
Hernández was scheduled to start at inside centre, charged with the task of sparking the backline of los Pumas into life.
But the 32-year-old, who is currently without a club after leaving Racing Métro, has withdrawn before kickoff, replaced by Santiago González Iglesias.
Jerónimo de la Fuente has come onto the bench.
Argentina (revised): 15 Joaquín Tuculet, 14 Horacio Agulla, 13 Marcelo Bosch, 12 Santiago González Iglesias, 11 Manuel Montero, 10 Nicolás Sánchez, 9 Martín Landajo, 8 Juan Manuel Leguizamón, 7 Juan Martín Fernández Lobbe, 6 Pablo Matera, 5 Tomás Lavanini, 4 Mariano Galarza, 3 Ramiro Herrera, 2 Agustín Creevy (c), 1 Marcos Ayerza.
Replacements: 16 Matías Cortese, 17 Lucas Noguera Paz, 18 Nahuel Tetaz Chaparro, 19 Matías Alemanno, 20 Leonardo Senatore, 21 Tomás Cubelli, 22 Jerónimo de la Fuente, 23 Lucas González Amorosino.