England will take on Wales in a one-off Sevens international staged immediately after Sunday's Six Nations contest at Twickenham.
The match showcasing the talents of the IRB Sevens World Series and Commonwealth Games rivals will be broadcast live.
The teams have met twice this season, England winning 33-12 in Dubai in December and 21-7 in Wellington last month.
With interest in Sevens booming ahead of its inclusion in the Olympic Games, a primetime slot in the middle of the Six Nations will expose the stars of the shortened form of the game to a new audience.
"We're delighted to be able to showcase international Sevens with England playing Wales on such a great stage in front of our fans," said RFU Chief Commercial Officer Sophie Goldschmidt.
"Our thanks go to the BBC who are helping us reach a live television audience via the Red Button with this special game.
"Sevens is exciting, dynamic and reaches a growing global following as it heads towards its debut at the Olympic Games in Rio in 2016.
"Both teams on view at Twickenham Stadium take part in a thriving World Series, which concludes with the London Sevens on May 10-11, and will be heading for the Commonwealth Games in Glasgow later this year with medals in mind."
"The whole squad is looking forward to the chance of being a part of such a massive rugby occasion at Twickenham Stadium," said England Sevens Head Coach Simon Amor.
"We get great support from the senior coaches and players, and our aim is to perform at a level that does them and the shirt proud as our players fight it out for places at the next two World Series tournaments in Tokyo and Hong Kong."
"Sevens is an important part of the England Rugby programme with an exciting future ahead in the build-up to the Commonwealth Games and we'll be wishing them well on Sunday," said England Head Coach Stuart Lancaster.
"England have a skilful and athletic squad and Sevens is a great spectacle so I know our fans will enjoy watching them in what should be a great game against Wales."
"This is a fantastic opportunity to be part of such a prestigious rugby occasion," said Wales Sevens Head Coach Gareth Williams.
"It also provides an opportunity for a number of our development players to stake a claim for a place in the squad to travel to Tokyo and Hong Kong later this month."