Defending LV=Cup champions Gloucester got their title defence off to a winning start on Saturday by running seven tries past Sale.
Northampton were easy winners over English rivals Saracens thanks to a hat-trick from Russian winger Vasily Artemyev on debut.
Harlequins maintained their unbeaten start to the season in all competitions against London Irish with a try at the death.
Bath inflicted a record-equalling home defeat on Dragons as they eased to victory at Rodney Parade while Worcester edged Wasps by a single point.
At Parc y Scarlets in Llanelli, the Scarlets registered an easy 31-3 victory over the Leicester Tigers and Newcastle thrashed the Cardiff Blues 33-3 at Kingston Park.
In Round One's final fixture, Exeter convincingly won the first ever match with the Ospreys.
Dragons 16-46 Bath
Northampton Saints 36-6 Saracens
Worcester Warriors 20-19 London Wasps
Harlequins 26-19 London Irish
Gloucester 58-27 Sale Sharks
Scarlets 31-3 Leicester Tigers
Newcastle Falcons 33-3 Cardiff Blues
Exeter Chiefs 35-9 Ospreys
Gloucester 58-27 Sale
Fly-half Freddie Burns contributed 26 points as a late flurry saw defending champions Gloucester start their campaign in fine style at Kingsholm with a bonus point win.
It was all-square at 27-27 after 55 minutes before the wheels came off the Sale bus.
Tries from Lesley Vainikolo and Jonny May gave the Cherry and Whites a 20-17 lead at the break.
Further tries followed from skipper Luke Narraway, Scott Lawson, Rory Lawson, Charlie Sharples and Burns saw the hosts gain revenge for last weekend's Premiership defeat against the same opposition.
Sale had three players sin-binned but put up a good fight with tries from Richie Vernon, Andrew Higgins and Rob Miller, while Nick Macleod contributed 12 points.
Gloucester: 15 Jonny May, 14 Charlie Sharples, 13 Henry Trinder, 12 Lesley Vainikolo, 11 James Simpson-Daniel 10 Freddie Burns, 9 Dave Lewis, 8 Luke Narraway, 7 Matt Cox, 6 Brett Deacon, 5 Will James, 4 Tom Savage, 3 Dario Chistolini, 2 Matias Cortese, 1 Dan Murphy.
Replacements: 16 Scott Lawson, 17 Yann Thomas, 18 Shaun Knight, 19 Jim Hamilton, 20 Alasdair Strokosch, 21 Rory Lawson, 22 Tim Taylor, 23 Tom Voyce
Sale Sharks: 15 Rob Miller, 14 Tom Brady, 13 Andrew Higgins, 12 Luther Burrell, 11 Charlie Amesbury, 10 Nick Macleod, 9 Scott Mathie, 8 Mark Easter, 7 David Seymour (capt ), 6 Richie Vernon, 5 James Gaskell, 4 Fraser McKenzie, 3 Vadim Cobilas, 2 Joe Ward, 1 Alasdair Dickinson
Replacements: 16 Tommy Taylor, 17 Lee Imiolek, 18 Tony Buckley, 19 Tom Holmes, 20 Kearnan Myall, 21 Will Cliff, 22 Johnny Leota, 23 Will Addison
Dragons 16-46 Bath
At Rodney Parade
Bath set a new record for a victory by a visiting side at Rodney Parade by scoring scored seven tries to match the 30-point winning margin achieved by the Scarlets six years ago.
But a serious-looking injury neck injury to scrum-half Mark McMillan spoiled Bath's day somewhat.
Olly Woodburn, Matt Banahan, Tom Biggs, Matt Carraro, Will Spencer, Jack Cuthbert, Anthony Perenise crossed for the English side while new recruit Tonderai Chavhanga replied for the Dragons.
Bath fly-half Tom Heathcote finished with a personal haul of 11 points.
Dragons: 15 Martyn Thomas, 14 Tonderai Chavhanga, 13 Tom Riley, 12 Lewis Robling, 11 Matthew Pewtner , 10 Matthew Jones, 9 Joe Bedford (c), 8 Nathan Williams, 7 Rhys Buckley, 6 Nathan Buck, 5 Royce Cadman, 4 Scott Morgan, 3 Jevon Groves, 2 Darren Waters, 1 Hugo Ellis
Replacements: 16 Sam Parry, 17 Hugh Gustafson, 18 Keiron Jenkins, 19 Rob Sidoli, 20 Tom Brown, 21 Wayne Evans, 22 Luke Williams, 23 Steffan Jones
Bath: 15 Jack Cuthbert, 14 Olly Woodburn, 13 Matt Carraro, 12 Matt Banahan, 11 Tom Biggs, 10 Tom Heathcote, 9 Mark McMillan, 8 Simon Taylor, 7 Guy Mercer, 6 Andy Beattie (c), 5 Dave Attwood, 4 Will Spencer, 3 Mark Lilley, 2 Ross Batty, 1 Charlie Beech
Replacements: 16 Will Tanner, 17 Nathan Catt, 18 Anthony Perenise, 19 Ryan Caldwell, 20 Will Skuse, 21 Chris Cook, 22 Paul Roberts, 23 Nick Abendanon.
Harlequins 26-19 London Irish
At Twickenham Stoop
A last-gasp try from Ollie Lindsay-Hague saw Harlequins claim victory deep into regulation time.
The England Sevens flyer touched down in the 84th minute as Quins snatched the spoils in a thrilling encounter.
Quins led 10-6 at half time thanks to an early try from Ben Urdapilleta, created by fly-half Rory Clegg.
The home pivot extended the lead from the kicking tee after the break but Exiles full-back Tom Homer pulled the visitors back into contention with few penalties of his own.
David Sisi put Irish ahead with try from short range in the 73rd minute but Lindsay-Hague's late converted try sealed the win for Quins.
Harlequins: 15 Tom Williams, 14 Seb Stegmann, 13 Ben Urudapilleta, 12 Tom Casson, 11 Sam Smith, 10 Rory Clegg, 9 Richard Bolt, 8 Chris York, 7 Will Skinner, 6 Luke Wallace, 5 Charlie Matthews, 4 Sam Twomey, 3 James Johnston, 2 Chris Brooker , 1 Joe Marler.
Replacements: 16 Rob Buchanan, 17 Mark Lambert, 18 Kyle Sinckler, 19 George Merrick, 20 Joe Trayfoot, 21 Olly Hauge, 22 Matt Hopper, 23 Charlie Walker.
London Irish: 15 Tom Homer; 14 Topsy Ojo; 13 Jonathan Spratt, 12 Guy Armitage, 11 Adam Thompstone, 10 Adrian Jarvis, 9, Paul Hodgson, 8 Alex Gray, 7 Jamie Gibson, 6 Declan Danaher, 5 Bryn Evans, 4 Nick Kennedy (Captain), 3 Faan Rautenbach, 2 James Buckland, 1 Max Lahiff
Replacements: 16 Brian Blaney, 17 Mark George, 18 Paulica Ion, 19 David Sisi, 20 Richard Thorpe, 21 Joe Ansbro, 22 Steven Shingler, 23 Ross Samson
Northampton 36-6 Saracens
At Franklin's Gardens
Russian winger Vasily Artemyev scored a hat-trick on his debut and Jamie Elliott bagged two tries as Saints cruised to victory.
Artemyev, who starred for Russia at the World Cup, score with his first touch of the ball in Saints colours to give the hosts a 7-0 lead.
The Russian fly scored his second try out on the wing soon after Saracens centre Kameli Ratuvou sin-binned for a deliberate knock-on.
Northpamton led 14-6 at the break after Ben Spencer landed two penalties for the visitors.
Ryan Lamb extended the lead with drop soon after the break before creating a third try for Artemyev with a smart grubber kick.
Elliott's converted try a few moments later wrapped up a bonus point for Saints.
Returning England internationals Dylan Hartley, Courtney Lawes and Tongan prop Soane Tonga'uiha came on as replacements, enhancing the hosts already dominant pack. Elliott touched down for his second try with five minutes remaining
Northampton: 15 Greig Tonks, 14 Jamie Elliott, 13 Scott Armstrong, 12 Tom May (capt), 11 Vasily Artemyev, 10