18-year-old Cumbrian winger Will Addison will make his debut for Sale in the LV=Cup in Leeds on Sunday.
19-year-old Iain Thornley also makes his first start for the Sharks, who will again be under coaches Byron Hayward and Pete Anglesea.
"What the young players showed against London Irish is that they are a lot more mature both physically and mentally than most of their counterparts," said Anglesea.
"They seemed to instantly adapt to senior rugby and it's a credit to those lads.
"They are mentally tough and mentally mature. They are not fazed and I don't want to knock that young players' mentality out of them as I want them to play without fear.
"If your gut instinct tells you it's the right thing, then I always think that's the way you should play. The moment you remove that they lose something."
Penrith-born winger Will Addison returned from injury to score two tries from full back in a friendly against Oxford University last Monday.
"He really stepped up to the mark and looked like a Chris Ashton type player and at the moment he's really special," Anglesea added.
Meanwhile, Leeds Carnegie have made a host of changes.
Only James Tincknell, Christian Lewis-Pratt, Warren Fury, Phil Nilsen and James Craig remain from the side who lost to Scarlets last week.
James Parkes, who is a member of the club's conditioning staff, has been drafted in to the squad following the injury to Andy Titterrell to cover at hooker. The former Gloucester hooker retired two years ago but has played in the club's A team in recent years.
Leeds Carnegie: 15 Michael Stephenson, 14 Lee Blackett, 13 James Tincknell, 12 Scott Barrow, 11 Peter Wackett, 10 Christian Lewis-Pratt, 9 Warren Fury, 8 Daniel Browne, 7 Jacob Rowan, 6 Rhys Oakley, 5 Marco Wentzel (c), 4 James Craig, 3 Juan Gomez, 2 Phil Nilsen, 1 Gareth Denman.
Replacements:16 James Parkes, 17 Miguel Alonso, 18 Phil Swainston, 19 Tom Denton, 20 Danny Paul, 21 Scott Mathie, 22 Ceiron Thomas, 23 Leigh Hinton.
Sale: 15 Nick Macleod, 14 Rhys Crane, 13 Fergus Mulchrone, 12 Iain Thornley, 11 Will Addison, 10 Matty James, 9 Dwayne Peel, 8 Asaeli Boko, 7 Neil McMillan, 6 Chris Brightwell, 5 Sean Cox (c), 4 Chris Jones, 3 Henry Thomas, 2 Ben Roberts, 1 Lee Imiolek.
Replacements:16 Neil Briggs, 17 Aston Croall, 18 Simon McIntyre, 19 Nic Rouse, 20 Dan Hall, 21 Will Cliff, 22 Chris Leck, 23 Anitelea Tuilagi
Date: Sunday, November 14
Venue: Headingley Carnegie
Kick-off: 15.00 GMT