Lock Eben Etzebeth and prop Frans Malherbe, have been released from the Springbok squad to play for WP in the opening round of the Currie Cup Premier Division on Friday.
Both players are returning from long-term injuries and will be allowed some game time for WP, against Eastern Province Kings in Port Elizabeth, to ease them back into the game.
Etzebeth's last game was in November 2013, for the Springboks against France in Paris, where he picked up a foot injury. Malherbe has been out for more than three months with concussion.
"Following medical assessments and consultation between our medical team and those of the various provinces, it was decided to release Eben and Frans for this weekend," said Springbok coach Heyneke Meyer.
"The provincial CEOs have all been part of the discussions on how to best manage our players and relating to the way in which injured players will return to the playing field.
"In the cases of Eben and Frans, who both have been out for extended periods of time, the Springboks' and Western Province's medical teams decided that the best course of action would be for them to get some game time this weekend."
Etzebeth and Malherbe, who have taken a full part in Springbok training since Monday afternoon, will join Western Province on Thursday.