Leinster and Ireland hooker Richardt Strauss will miss the rest of the season following the discovery of a heart condition.
The South Africa-born Strauss has been with Leinster since 2009 and qualified to play for his adopted country on residency last year.
Following the result of extensive medical tests, it has emerged that Strauss has been diagnosed with a heart condition and will be unavailable for selection for the remainder of the season.
The Leinster management are confident that the 27-year-old, who is set to undergo surgery this week, will make a full recovery and will provide him with the best care in his recovery.
Other squad news includes that Lote Tuqiri has suffered a recurrence of the hamstring strain which has curtailed him in recent weeks and he is set for a further spell on the sidelines. It is hoped that he will be available for the Round Two game against Castres at the RDS.
Brian O'Driscoll (calf strain) has a 50/50 chance of being fit and will continue to receive treatment from the medical team this week ahead of Friday's team announcement, though at this stage the Ireland centre hasn't been ruled out of the selection mix.
Better news for the province is the arrival of Springbok international Zane Kirchner who has finally linked up with the province following a series of impressive displays in The Rugby Championship.
Kirchner, who featured against the All Blacks in Ellis Park on Saturday, will train with his new team-mates this week and could come into the frame.