Munster prop BJ Botha has been ruled out for around four weeks due to grade two medial ligament injury to his right knee.
Botha sustained the injury in Munster's final pre-season friendly against London Irish last weekend.
The former Springbok's absence will allow some of Munster's younger props to play a major role in the coming weeks, starting when they take on Edinburgh in the opening round of the RaboDirect Pro12 this weekend.
"We're lucky that we have some good young talent coming through and it's exciting that these younger players will get a chance to show what they're worth," said Munster head coach Rob Penney.
Munster are set to be without centres Andrew Conway and James Downey for Saturday's match, with British and Irish Lions trio Simon Zebo, Paul O'Connell and Conor Murray also yet to return.
"We play them (Edinburgh) four times this season between the league and the Heineken Cup so it's important we start strongly," added Penney.
"We learned a lot last season and believe we have a squad that has the depth to be competitive.
"We've lost some irreplaceable players like Ronan O'Gara but we have strengthened in areas too and the competition for places will be tough.
"This is an opportunity for guys to take their chance in these early games and I'm looking forward to seeing how the guys go."