The Scarlets have made six personnel changes to their line-up that will take on Treviso, with a number of players swapping positions on Saturday.
Up-and-coming young back Jordan Williams, gets a start at full-back after his impressive form away in Connacht which won him the man of the match gong. Liam Williams moves to the right wing.
Last year's vice-captain Gareth Maule comes into the centre to partner Jonathan Davies who switches to inside centre. Rhys Priestland is at fly-half with Gareth Davies, who achieved his 50th appearance for the region last week, getting his chance at nine. Tavis Knoyle moves to the bench.
Matthew Rees starts at hooker and Sione Timani partners with George Earle in the second-row. Experienced Scarlets back-rower Johnathan Edwards comes back into the line-up with Josh Turnbull moving to six and captain
"There are some changes to ensure we give game time to as many of the squad as we can before Europe and it takes into account the amount of rugby some of our players have already put in; so George (North) and Scott (Williams) get some time off the field this weekend," said head coach Simon Easterby.
"It's great to see young talent like Jordan Williams stepping up; he's impressed us and he has great versatility as a player which we want to encourage. He's still developing and we need to be mindful of that but we also know he has the ability do things that not many players can.
"This region has consistently invested in its younger players and given opportunities with the philosophy that if you're good enough you're old enough."
Meanwhile, Treviso head coach Franco Smith has brought in Tommaso Iannone on the left wing in the only change to the backline while he tweaks a few in the forward pack.
Lorenzo Cittadini is back as tighthead prop, while Michele Rizzo is loosehead.
Captain Antonio Pavanello and Valerio BernabÃ² form a completely new second-row, with Simone Favaro returning in the back-row.
Form: Benetton Treviso have won just one of their last six RaboDirect PRO12 encounters: 12-6 over Ospreys at Stadio Monigo on the opening day of the new season. Treviso have won two of their last three games against the Welsh regions. Scarlets' four game winning run ended at home to Ospreys on Friday, but they still sit atop the PRO12 table. Scarlets have won their last three away games but have not won four in a row on the road in the tournament since May 2004. Each side won its respective home game when the two teams met last season, whilst the men from West Wales' only previous win in Treviso came during the pool games in the 2010/11 European Cup.
Rugby Union betting odds
Treviso: 15 Luke McLean, 14 Tommaso Benvenuti, 13 Alberto Sgarbi, 12 Luca Morisi, 11 Tommaso Iannone, 10 Kristopher Burton, 9 Tobias Botes, 8 Robert Barbieri, 7 Alessandro Zanni, 6 Simone Favaro, 5 Valerio BernabÃ², 4 Antonio Pavanello (capt), 3 Lorenzo Cittadini, 2 Leonardo Ghiraldini, 1 Michele Rizzo.
Replacements: 16 Franco Sbaraglini, 17 Ignacio Fernandez-Rouyet, 18 Pedro Di Santo, 19 Francesco Minto, 20 Dean Budd, 21 Paul Derbyshire, 22 Fabio Semenzato, 23 Alberto Di Bernardo.
Scarlets: 15 Jordan Williams, 14 Liam Williams, 13 Gareth Maule, 12 Jon Davies, 11 Andy Fenby, 10 Rhys Priestland, 9 Gareth Davies, 8 Rob McCusker (capt), 7 Johnathan Edwards, 6 Josh Turnbull, 5 George Earle, 4 Sione Timani, 3 Deacon Manu, 2 Matthew Rees, 1 Phil John.
Replacements: 16 Ken Owens, 17 Peter Edwards, 18 Samson Lee, 19 Aaron Shingler, 20 Kieran Murphy, 21 Tavis Knoyle, 22 Adam Warren, 23 Kristian Phillips.
Date: Satuday, September 29
Kick-off: 19:05 local (18:05 BST)
Venue: Stadio Monigo
Referee: Andrew McMenemy (Scotland)
Assistant referees: Carlo Damasco (Italy), Simone Boaretto (Italy)
Television match official: Alan Falzone (Italy)